1-(1-Naphthyl)piperazine

SKU: orb3174259

描述

1-(1-Naphthyl)piperazine is a modulator of 5-HT receptors, acting both as a 5-HT2A receptor antagonist and a 5-HT1A receptor agonist, with a human 5-HT6 receptor binding constant (Ki) of 120 nM. It partially inhibits forskolin-stimulated adenylate cyclase activity in bovine substantia nigra and can suppress UV radiation-induced immunosuppression. Additionally, 1-(1-Naphthyl)piperazine induces S-phase cell cycle delay, apoptosis, and increases reactive oxygen species (ROS) levels, leading to the inhibition of MNT-1 cell proliferation. This compound is utilized in melanoma research.

研究领域

Cell Biology, Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

图片与验证

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关键属性

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CAS 号	57536-86-4
MW	212.2902
分子式	C₁₄H₁₆N₂
SMILES	C1CN(CCN1)C1=C2C=CC=CC2=CC=C1
靶点	5-HT Receptor,AChR,ROS,Apoptosis

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

相似产品

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1-(1-Naphthyl) piperazine hydrochloride [orb1306295]
纯度：
98.80% (May vary between batches)
CAS 号：
104113-71-5
MW:
248.75
分子式：
C₁₄H₁₇ClN₂
可选规格： 10 mg, 25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO)

质量保证

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常用数据库链接

基因符号

5-HT Receptor,AChR,ROS,Apoptosis

实验方案信息

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