4-Phenylbutyric acid

SKU: orb1301408

描述

4-Phenylbutyric acid is a small molecule functioning as both a histone deacetylase (HDAC) inhibitor and an endoplasmic reticulum stress (ERS) alleviator. It is utilized in research areas including cancer, neurodegeneration, and metabolic disorders, with applications in both cellular and animal models to study protein misfolding and gene expression.

研究领域

Epigenetics & Chromatin, Infectious Disease & Virology, Molecular Biology

图片与验证

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关键属性

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CAS 号	1821-12-1
MW	164.2011
纯度	99.76% (May vary between batches)
分子式	C₁₀H₁₂O₂
SMILES	OC(=O)CCCC1=CC=CC=C1
靶点	HDAC,Virus Protease
溶解性	DMSO:262.5 mg/mL (1598.66 mM);H2O:1.65 mg/mL (10.05 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:12.5 mg/mL (76.13 mM)

生物活性

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体内

METHODS: To study the effects on obese mice, 4-Phenylbutyric acid (120 mg/kg) was administered intraperitoneally to KK-Ay mice fed Lieber-DeCarli diet (5% EtOH) once daily for ten days. On day 11, a single dose of EtOH (4 g/kg) was administered by gavage. RESULTS: In an obese mouse model, chronic overdose of EtOH induced massive ER stress-related oxidative stress and liver injury through dysregulation of unfolded protein responses. 4-Phenylbutyric acid ameliorated the liver injury induced by chronic addition of overdose of EtOH by decreasing ER and oxidative stress after overdose of EtOH.

体外

METHODS: ERp57 KO and control cells were treated with 4-Phenylbutyric acid (50 mM) and protein expression levels were detected by Immunoblot analysis. RESULTS: Levels of ER stress marker proteins BiP, Chop and IRE1 were increased in ERp57 KO cells compared to control cells, indicating higher levels of ER stress in the absence of ERp57. 50 mM 4-Phenylbutyric acid treatment was effective in ERp57 KO cells and reduced protein levels of all three ER stress markers. protein levels of all three ER stress markers. In the case of IRE1, ER stress proteins were even reduced below the levels of control cells. METHODS: A549 cells and primary nasal epithelial cells were treated with 4-Phenylbutyric acid (0-20 mM) for 72 h. Cell viability was measured by MTT assay. RESULTS: Cells were examined after treatment with 4-Phenylbutyric acid concentrations ranging from 0-20 mM, and cell survival was not affected below 10 mM.

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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Benzenebutyric acid, 4-PBA, 4Phenylbutyric acid, 4-Phenylbutyric acid, 4 Phenylbutyric acid, Inhibitor, HDAC, Histone deacetylases, inhibit, Virus Protease, VirusProtease

相似产品

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Phenibut (hydrochloride) [orb1298755]
纯度：
99.93% (May vary between batches)
CAS 号：
3060-41-1
MW:
215.68
分子式：
C₁₀H₁₄ClNO₂
可选规格： 1 ml x 10 mM (in DMSO), 25 mg
Phenibut (hydrochloride) [orb1219934]
纯度：
>98% (HPLC)
CAS 号：
3060-41-1
MW:
215.68
分子式：
C₁₀H₁₄ClNO₂
可选规格： 100 mg, 200 mg, 500 mg, 1 g
Benzenebutyric acid [orb1220618]
纯度：
>98% (HPLC)
CAS 号：
1821-12-1
MW:
164.2
分子式：
C₁₀H₁₂O₂
可选规格： 500 mg, 1 g

质量保证

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化合物标识

PubChem CID

4775 ↗

关键属性

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暂无计算属性。

实验方案信息

查看更多实验方案

纯度：	99.93% (May vary between batches)
CAS 号：	3060-41-1
MW:	215.68
分子式：	C₁₀H₁₄ClNO₂

纯度：	>98% (HPLC)
CAS 号：	3060-41-1
MW:	215.68
分子式：	C₁₀H₁₄ClNO₂

4-Phenylbutyric acid

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

相似产品

Phenibut (hydrochloride) [orb1298755]

Phenibut (hydrochloride) [orb1219934]

Benzenebutyric acid [orb1220618]

质量保证

化合物标识

关键属性

实验方案信息

可选规格