4A3-SCC-PH

SKU: orb2703758

描述

4A3-SCC-PH is a groundbreaking linker-degradable ionizable lipid (LDIL) that features a glutathione (GSH)-responsive cone-shaped molecular structure. This unique architecture enables superior endosomal escape and rapid mRNA release, making it highly effective for mRNA delivery. In vivo studies have highlighted its exceptional performance, showing a 176-fold increase in mRNA delivery efficiency to the liver compared to DLin-MC3-DMA, a widely used benchmark lipid. Both 4A3-SCC-PH and its structural analog, 4A3-SCC-10, also demonstrated significantly enhanced mRNA delivery efficacy compared to their non-disulfide-containing parent compounds and disulfide-containing controls with modified lipid tails.

图片与验证

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关键属性

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MW	1948.094
纯度	>95%
分子式	C₉₁H₁₇₁N₃O₁₆S₁₂
SMILES	CN(CCCN(CCC(OCCSSCCOC(C(C)CSCC(CCC)CCCCC)=O)=O)CCC(OCCSSCCOC(C(C)CSCC(CCC)CCCCC)=O)=O)CCCN(CCC(OCCSSCCOC(C(C)CSCC(CCC)CCCCC)=O)=O)CCC(OCCSSCCOC(C(C)CSCC(CCC)CCCCC)=O)=O

储存与操作

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有效期	12 months from date of receipt.
免责声明	For research use only

相似产品

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4A3-SCC-PH [orb2813952]
MW:
1948.12
分子式：
C₉₁H₁₇₁N₃O₁₆S₁₂
可选规格： 10 mg, 50 mg

质量保证

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化合物标识

PubChem CID

175667366 ↗

关键属性

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暂无计算属性。

实验方案信息

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MW:	1948.12
分子式：	C₉₁H₁₇₁N₃O₁₆S₁₂

4A3-SCC-PH

描述

图片与验证

关键属性

储存与操作

相似产品

4A3-SCC-PH [orb2813952]

质量保证

化合物标识

关键属性

实验方案信息

可选规格