ATIC-IN-1 acetate

SKU: orb1944638

描述

ATIC-IN-1 acetate is a small molecule inhibitor that targets the ATIC enzyme by preventing its dimerization, thereby blocking its AICAR transformylase activity. This mechanism confers potential anti-tumor properties, making it a useful tool for investigating purine biosynthesis in cancer research, both in vitro and in vivo.

研究领域

Metabolism Research

图片与验证

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关键属性

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MW	523.59
纯度	99.89% (May vary between batches)
分子式	C₂₃H₃₇N₇O₇
SMILES	O=[N+](C1=CC=C(C[C@H](NC([C@H](CCCNC(N)=N)NC(C)=O)=O)C(N(CC)CC)=O)C=C1)[O-].CC(O)=O
靶点	Endogenous Metabolite,Others
溶解性	10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (3.82 mM);DMSO:40 mg/mL (76.4 mM);H2O:40 mg/mL (76.4 mM)

生物活性

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靶点 IC50

aminoimidazolecarboxamide ribonucleotide translocase/inosine monophosphate cyclization hydrolase (ATIC):685 nM （Ki）

体外

ATIC-IN-1 acetate (Compound 14) is an inhibitor of aminoimidazolecarboxamide ribonucleotide translocase/inosine monophosphate cyclization hydrolase (ATIC) dimerization with a Ki value of 685 nM. ATIC-IN-1 acetate (100-500 μM, treated for 48 hours) was able to hinder the proliferation of MCF-7 cells. ATIC-IN-1 acetate (250 μM, 24-72 hours of action) decreases cell division rather than increasing cell death.

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

质量保证

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化合物标识

PubChem CID

171326037 ↗

关键属性

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暂无计算属性。

实验方案信息

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ATIC-IN-1 acetate

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

质量保证

化合物标识

关键属性

实验方案信息

可选规格