AVS Bio - WNT Surrogate-Fc Fusion Protein

The Wnt signaling pathway is essential for embryonic development, stem cell differentiation and regeneration of injured tissues. Wnts hetero-dimerize Frizzled (Fzd) family receptors and their co-receptors Lrp5/6, triggering downstream signaling pathways including the canonical β-catenin cascade, and resulting in expression of genes regulating cell development. Due to its critical roles in development, Wnt has been widely used as an essential cell growth factor in organoids, a rapidly developing model system for tissue development. Currently, recombinant Wnt3a is commonly used as Wnt source. Unfortunately, recombinant Wnt3a is water insoluble and cannot serve as a medium supplement. Recombinant Wnt Surrogate-Fc Fusion-protein has an excellent solubility, and a better wnt response at lower effective concentrations than other sources of Wnt3a. WNT Surrogate-Fc Fusion-protein supports longterm expansion of multiple different types of organoids, including intestinal, kidney, colon, hepatocyte, ovarian, and breast organoids.