Cholesterol (animal-free)

SKU: orb1310316

描述

Cholesterol is a fundamental mammalian sterol constituting 20–25% of the plasma membrane, where it modulates fluidity and permeability. As an endogenous ERRα agonist and precursor for hormones and bile acids, it is integral to metabolic studies and is commonly employed in hyperlipidemia research models, both in vitro and in vivo.

研究领域

Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research

图片与验证

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Item 1 of 1

关键属性

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CAS 号	57-88-5
MW	386.6535
纯度	99.95% (May vary between batches)
分子式	C₂₇H₄₆O
SMILES	CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C
靶点	Endogenous Metabolite,Estrogen Receptor/ERR,Antibacterial,MRP,ROR,Liposome
溶解性	H2O:< 1 mg/mL (insoluble);Ethanol:11.42 mg/mL (29.54 mM);DMSO:< 1mg/mL (insoluble)

生物活性

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体内

METHODS: To induce hypercholesterolemia, STD:ddY mice were fed a high cholesterol diet (1% cholesterol, 0.5% cholic acid, 0.5% olive oil and 93% standard mouse chow). RESULTS: Cholesterol can be used to construct a mouse model of hypercholesterolemia. METHODS: To induce hyperlipidemia, CD-1 mice were fed a high cholesterol diet (2% cholesterol and 0.6% sodium deoxycholate). RESULTS: Cholesterol can be used to construct a mouse model of hyperlipidemia.

体外

METHODS: CD4+ T lymphocytes were incubated with 7-KC (17.5-70 µM) and Cholesterol-MβCD (17.5-70 µM) for 10 min, and T cell membrane order and disorder were assessed using di-4 ANEPPDHQ fluorescent dye. RESULTS: After exposure to 7-KC, T cell membrane order was altered in a dose-dependent manner, with significant reconstitution of membrane order observed only in cells treated with 35 µM Cholesterol, while reconstitution with l7.5 µM Cholesterol induced minimal effects. METHODS: Human gastric cancer cells SNU601, SNU638 and SNU216 were treated with Cholesterol (25-100 µM) for 48 h and cell viability was measured using MTT Assay. RESULTS: Cholesterol caused a dose-dependent decrease in cell viability in all three cell lines.

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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signaling, phosphorylation, RORα, SREBP2, transporters, unesterified, inhibit, MRP1, IRS-1, insulin, Inhibitor, Endogenous Metabolite, EndogenousMetabolite, exocytic, ERR, ERRα, Estrogen Receptor, EstrogenReceptor, Estrogen Receptor/ERR, Diabetes, Cholesteryl alcohol, Cholesterin, Cholesterol, AKT

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质量保证

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our 条款与条件和选购指南.

化合物标识

PubChem CID

304 ↗

关键属性

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暂无计算属性。

实验方案信息

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Cholesterol (animal-free)

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

相似产品

Human Galectin-4 Protein, His tag (Animal-Free) [orb3148439]

质量保证

化合物标识

关键属性

实验方案信息

可选规格