Choline Fenofibrate

SKU: orb1223844

描述

A PPARα agonist used for treatment of hyperlipidemia; increases SHP gene expression in cultured liver cells and in the normal and diabetic mouse liver by activating AMPK signaling pathway.Hypercholesterolemia Approved(In Vivo):Choline Fenofibrate exhibits excellent absolute oral bioavailability (rat 93.4%) and Cmax (rat 7944.2 ng/mL) following oral administration (rat 4mg/kg).Choline Fenofibrate exhibits terminal elimination half-life (rat 5.4 h) following intravenous injection (rat 4mg/kg).

研究领域

Pharmacology & Drug Discovery

图片与验证

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关键属性

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CAS 号	856676-23-8
MW	421.9144
纯度	>98% (HPLC)
分子式	C₂₂H₂₈ClNO₅
SMILES	OCC[N+](C)(C)C.CC(C)(OC1=CC=CC=C1C(C2=CC=C(Cl)C=C2)=O)C([O-])=O
靶点	PPAR
溶解性	DMSO: 6.2 mg/mL (Need ultrasonic and warming)

生物活性

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体内

Choline Fenofibrate exhibits excellent absolute oral bioavailability (rat 93.4%) and Cmax (rat 7944.2 ng/mL) following oral administration (rat 4 mg/kg). Choline Fenofibrate exhibits terminal elimination half-life (rat 5.4 h) following intravenous injection (rat 4 mg/kg). Animal model: Male Sprague-Dawley (SD) rats (200-250g). Dosage: 4 mg/kg (Pharmacokinetic Analysis). Administration: Intravenous injection and oral administration. Result: Oral bioavailability (93.4%), Cmax (7944.2 ng/mL), T1/2 (5.4 h).

储存与操作

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储存	Storage temperature: -20°C. Stability: ≥ 2 years
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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ABT-335 | ABT 335 | ABT335

相似产品

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Choline Fenofibrate [orb1303534]
纯度：
99.95% (May vary between batches)
CAS 号：
856676-23-8
MW:
421.91
分子式：
C₂₂H₂₈ClNO₅
可选规格： 10 mg, 25 mg, 100 mg, 5 mg, 50 mg, 200 mg

质量保证

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常用数据库链接

基因符号

PPAR

实验方案信息

查看更多实验方案

纯度：	99.95% (May vary between batches)
CAS 号：	856676-23-8
MW:	421.91
分子式：	C₂₂H₂₈ClNO₅