CXCR6 inhibitor 81

SKU: orb2279718

描述

CXCR6 inhibitor 81 is a potent (EC50=40 nM) and selective orally bioavailable small molecule antagonist of human CXCR6 receptor; Compound 81 displays >10-fold improvement in potency in both the β-arrestin and cAMP assays (IC50 =40 and 540 nM, respectively) compared to ML339. CXCR6 inhibitor 81 inhibits migration of SK-HEP-1 hepatoma cells in a dose dependent manner. Compound 81 has promising oral DMPK data, significantly decreases tumor growth in a 30-day mouse xenograft model of HCC.

研究领域

Immunology & Inflammation; Pharmacology & Drug Discovery

图片与验证

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关键属性

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CAS 号	2579689-85-1
MW	549.605016231537
纯度	>98%
分子式	C₂₇H₃₀F₃N₃O₄S
SMILES	C(NC1CC2N(CC3=NC4=C(C(F)(F)F)C=CC=C4S3)C(CCC2)C1)(=O)C1=CC(OC)=C(OC)C(OC)=C1

储存与操作

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有效期	12 months from date of receipt.
免责声明	For research use only

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化合物标识

PubChem CID

155574214 ↗

关键属性

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暂无计算属性。

实验方案信息

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CXCR6 inhibitor 81

描述

研究领域

图片与验证

关键属性

储存与操作

质量保证

化合物标识

关键属性

实验方案信息

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