DHRS11-IN-1

SKU: orb3211420

描述

DHRS11-IN-1 is an inhibitor of the short-chain dehydrogenase/reductase family member 11 (DHRS11), with an IC50 value of 0.037 μM. It binds to DHRS11 and forms a hydrogen bond with the His210 residue of the enzyme. DHRS11-IN-1 suppresses androgen receptor mRNA and protein expression, reduces c-Myc levels, and inhibits cancer cell proliferation. It also impedes the PI3K/AKT signaling pathway by decreasing the phosphorylation of PDK1, AKT, mTOR, and ERK. Additionally, DHRS11-IN-1 enhances Capivasertib-induced cytotoxicity and apoptosis (apoptosis). This compound can be applied in studies related to luminal androgen receptor-positive triple-negative breast cancer.

图片与验证

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关键属性

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靶点	Apoptosis,Akt,c-Myc,Androgen Receptor,PI3K,ERK,PDK,mTOR

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

质量保证

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常用数据库链接

基因符号

Apoptosis,Akt,c-Myc,Androgen Receptor,PI3K,ERK,PDK,mTOR

实验方案信息

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