DLin-KC2-DMA

SKU: orb1308377

描述

DLin-KC2-DMA is an ionizable cationic lipid utilized for siRNA delivery in lipid nanoparticles (LNPs). It enables effective gene silencing, such as targeting GAPDH, in both in vitro and in vivo research applications for therapeutic development.

研究领域

Immunology & Inflammation, Metabolism Research

图片与验证

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Item 1 of 1

关键属性

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CAS 号	1190197-97-7
MW	642.09
纯度	98.60% (May vary between batches)
分子式	C₄₃H₇₉NO₂
SMILES	CCCCC\C=C/C\C=C/CCCCCCCCC1(CCCCCCCC\C=C/C\C=C/CCCCC)OCC(CCN(C)C)O1
靶点	Others,Liposome
溶解性	Ethanol:50 mg/mL (77.87 mM);DMSO:100 mg/mL (155.74 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.23 mM)

生物活性

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体内	METHODS: C57Bl6 mice were injected with DLinKC2-DMA-formulated LNP siRNA (5 mg/kg, tail vein injection) via the tail vein to study the in vivo gene silencing properties of DLinKC2-DMA-formulated LNP siRNA. RESULTS DLinKC2-DMA effectively silenced target genes in APcs in vivo.
体外	METHODS: Macrophages (MΦ) and dendritic cells (DC) were treated with DLinKC2-DMA (1,5μg/mL) to observe the effect of DLinKC2-DMA on siRNA-mediated gene silencing. GAPDH and control α-tubulin expression were evaluated using Western blot analysis and flow cytometry. RESULTS At a dose level of 5μg/ml, LNPs containing DLinKC2-DMA were again the most effective gene silencing agents.

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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DLin KC2 DMA, DLinKC2DMA, DLin-KC-2-DMA, DLin-KC2-DMA, inhibit, Inhibitor

质量保证

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化合物标识

PubChem CID

44464860 ↗

关键属性

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暂无计算属性。

实验方案信息

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DLin-KC2-DMA

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

质量保证

化合物标识

关键属性

实验方案信息

可选规格