DN1679

SKU: orb3177177

描述

DN1679 is a potent, selective, and orally active CRBN-dependent dual degrader of CDK12/13 PROTAC. It exhibits DC50 values for CDK12/13 at 8.8/9.8 nM in MDA-MB-231 cells, 5.1/6.4 nM in MDA-MB-157 cells, and 17.2/15.8 nM in MDA-MB-468 cells. DN1679 downregulates mRNA levels of DNA damage response genes such as ATM, ATR, BRCA1, and RAD51. When used in combination with Olaparib, DN1679 shows a significant synergistic anti-tumor effect. It is applicable in research on triple-negative breast cancer.

研究领域

Cell Biology, Pharmacology & Drug Discovery

图片与验证

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关键属性

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靶点	CDK,PROTACs

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

相似产品

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Thalidomide-6-F-5-pip-CHO [orb3177181]
CAS 号：
2505502-00-9
MW:
387.37
分子式：
C₁₉H₁₈FN₃O₅
可选规格： 10 mg, 50 mg
CDK12/13 ligand 3 [orb3177219]
可选规格： 50 mg, 10 mg

质量保证

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常用数据库链接

基因符号

CDK,PROTACs

实验方案信息

查看更多实验方案

CAS 号：	2505502-00-9
MW:	387.37
分子式：	C₁₉H₁₈FN₃O₅