Domatinostat

SKU: orb1300834

描述

Domatinostat (4SC202) is a selective class I HDAC inhibitor targeting HDAC1, HDAC2, and HDAC3, and also inhibits LSD1. It has been investigated in Phase 1 clinical trials for oncology research, with studies demonstrating its activity in both in vitro cellular assays and in vivo cancer models.

研究领域

Cell Biology, Epigenetics & Chromatin, Molecular Biology

图片与验证

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关键属性

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CAS 号	910462-43-0
MW	447.51
纯度	99.74% (May vary between batches)
分子式	C₂₃H₂₁N₅O₃S
SMILES	Cn1cc(cn1)-c1ccc(cc1)S(=O)(=O)n1ccc(\C=C\C(=O)Nc2ccccc2N)c1
靶点	HDAC,Apoptosis
溶解性	DMSO:82 mg/mL (183.24 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.37 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble)

生物活性

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靶点 IC50	HDAC2:1.12 μM\|HDAC1:1.20 μM\|HDAC9:50 μM\|HDAC5:11.3 μM\|HDAC10:21 μM\|HDAC3:0.57 μM\|HDAC11:9.7 μM
体内	In vivo, 4SC-202 has a high oral bioavailability, and shows high metabolic stability and a low plasma clearance. 4SC-202 (120 mg/kg p.o.) shows pronounced and robust anti-tumor activity in both A549 NSCLC xenograft and RKO27 colon carcinoma model.
体外	In HeLa cells, 4SC-202 induces hyperacetylation of histone H3 with EC50 of 1.1 μM. 4SC-202 induces a G2/M cell cycle arrest by interfering with the normal development of the mitotic spindle and causing collapsed spindle apparatus and multiple nucleation centres. In addition, 4SC-202 shows a broad anti-proliferative activity towards human cancer cell lines with a mean IC50 of 0.7 μM.

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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Domatinostat, 4SC202, 4SC-202, 4SC-202 (free base), 4SC 202, Apoptosis, inhibit, Histone deacetylases, Inhibitor, HDAC, HDAC3, HDAC5, HDAC2, HDAC1, HDAC11

相似产品

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Domatinostat tosylate [orb1302825]
纯度：
>99.99% (May vary between batches)
CAS 号：
1186222-89-8
MW:
619.71
分子式：
C₃₀H₂₉N₅O₆S₂
可选规格： 25 mg, 5 mg, 10 mg, 50 mg, 100 mg, 1 mg, 1 ml x 10 mM (in DMSO)
4SC-202 free base [orb1223678]
纯度：
>98% (HPLC)
CAS 号：
910462-43-0
MW:
447.51
分子式：
C??H??N?O?S
可选规格： 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g

质量保证

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our 条款与条件和选购指南.

化合物标识

PubChem CID

15985904 ↗

关键属性

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暂无计算属性。

实验方案信息

查看更多实验方案

纯度：	>99.99% (May vary between batches)
CAS 号：	1186222-89-8
MW:	619.71
分子式：	C₃₀H₂₉N₅O₆S₂

纯度：	>98% (HPLC)
CAS 号：	910462-43-0
MW:	447.51
分子式：	C??H??N?O?S

Domatinostat

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

相似产品

Domatinostat tosylate [orb1302825]

4SC-202 free base [orb1223678]

质量保证

化合物标识

关键属性

实验方案信息

可选规格