DOPE

SKU: orb1307144

特色

描述

DOPE is a neutral helper lipid used to formulate cationic liposomes for non-viral gene delivery. It enhances transfection efficiency in both in vitro and in vivo studies by promoting membrane fusion and endosomal escape during DNA delivery applications.

研究领域

Metabolism Research

图片与验证

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关键属性

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CAS 号	4004-05-1
MW	744.03
纯度	≥98% (May vary between batches)
分子式	C₄₁H₇₈NO₈P
SMILES	CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC
靶点	Others,Endogenous Metabolite,Liposome
溶解性	Ethanol:10 mg/mL (13.44 mM);DMSO:< 1 mg/mL (insoluble or slightly soluble)

生物活性

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靶点 IC50

Helper lipid for liposome:

体外

Each siRNA is encapsulated in LNP (cationic lipid-A: PEG2000-DMPE: DOPE = 47.8: 5.18: 47.1 molar percent). With the neutral lipid for the LNP is DOPE, LNP exerts knock-down (KD) effect on macrophages and DCs and Liposome-containing DOPE shows fusogenicity. LNP/siRNA significantly suppresses CD45 protein expression at an inhibition rate of 30% on macrophages and DCs but not on monocytes, neutrophils, plasmacytoid DCs, or B cells.

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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1,2Dioleoylsnglycero3phosphoethanolamine, 1,2 Dioleoyl sn glycero 3 phosphoethanolamine, cationic, DNA, dioleoylphosphatidylethanolamine, Inhibitor, emulsifier, liposome, knock-down, inhibit, transfection, siRNA, phospholipid

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Item 1 of 1
246C10 [orb1473189]
纯度：
>95%
CAS 号：
2635329-26-7
MW:
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分子式：
C₅₈H₁₂₀N₄O₄
可选规格： 25 mg, 10 mg, 100 mg
Lipid H7T4-4 [orb3033089]
纯度：
0.98
MW:
1021.78
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C₆₄H₁₃₂N₄O₄
可选规格： 25 mg, 50 mg
4A3-SC7 [orb3033125]
纯度：
0.98
CAS 号：
1857340-77-2
MW:
1411.07
分子式：
C₇₁H₁₃₁N₃O₁₆S₄
可选规格： 25 mg, 50 mg, 100 mg
Lipid S4 [orb3033130]
纯度：
>98%
MW:
860.65
分子式：
C₅₀H₈₉ClN₄O₅
可选规格： 10 mg, 25 mg, 50 mg
DOPE-PEG-NBD [orb2647151]
纯度：
>98%
可选规格： 100 mg

质量保证

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our 条款与条件和选购指南.

化合物标识

PubChem CID

9546757 ↗

关键属性

−

暂无计算属性。

实验方案信息

查看更多实验方案

纯度：	>95%
CAS 号：	2635329-26-7
MW:	937.6
分子式：	C₅₈H₁₂₀N₄O₄

纯度：	0.98
MW:	1021.78
分子式：	C₆₄H₁₃₂N₄O₄

纯度：	>98%
MW:	860.65
分子式：	C₅₀H₈₉ClN₄O₅

DOPE

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

相似产品

246C10 [orb1473189]

Lipid H7T4-4 [orb3033089]

4A3-SC7​​ [orb3033125]

Lipid S4 [orb3033130]

DOPE-PEG-NBD [orb2647151]

质量保证

化合物标识

关键属性

实验方案信息

可选规格

4A3-SC7 [orb3033125]