DOTAP chloride

SKU: orb1309745

描述

DOTAP chloride (1, 2-dioleoyl-3-trimethylammonium-propane chloride) is an efficient cationic lipid, and its target is mainly the negatively charged components on the cell membrane. DOTAP chloride binds to negatively charged nucleic acids (such as DNA and RNA) by electrostatic interaction to form complexes, thereby achieving the delivery of nucleic acids.

研究领域

Metabolism Research

图片与验证

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关键属性

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CAS 号	132172-61-3
MW	698.542
纯度	>99.99% (May vary between batches)
分子式	C₄₂H₈₀ClNO₄
SMILES	CCCCCCCC/C=C\CCCCCCCC(OCC(OC(CCCCCCC/C=C\CCCCCCCC)=O)C[N+](C)(C)C)=O.[Cl-]
靶点	Others,Liposome
溶解性	Ethanol: 130 mg/mL (186.1 mM), Sonication and heating are recommended. DMSO: 125 mg/mL (178.94 mM), Sonication is recommended.

生物活性

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靶点 IC50	293T cells:58.6 µM
体外	METHODS: Prostate cancer cell line PC3 and melanoma cell line M21 were treated with paclitaxel (PTX) loaded on DOTAP/DOPC liposome carriers (CLs) for 24 hours. The cytotoxicity was detected by measuring the absorbance at 490 nm using an enzyme-linked immunosorbent assay reader. RESULTS: With the increase of PTX content, the cytotoxic effect of DOTAP/DOPC CLs is enhanced.

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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Lipid, Inhibitor, inhibit, nucleic, DOTAP, DOTAP chloride, DOTAP Chloride, Cationic Lipid, Cationic, acid, 1,2-Dioleoyl-3-trimethylammonium-propane Chloride, 1,2-Dioleoyl-3-trimethylammonium-propane chloride, transfection

相似产品

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DOTAP chloride [orb1218933]
纯度：
>98% (HPLC)
CAS 号：
132172-61-3
MW:
698.54
分子式：
C₄₂H₈₀ClNO₄
可选规格： 50 mg, 100 mg, 500 mg, 1 g, 200 mg

质量保证

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化合物标识

PubChem CID

129009514 ↗

关键属性

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暂无计算属性。

实验方案信息

查看更多实验方案

纯度：	>98% (HPLC)
CAS 号：	132172-61-3
MW:	698.54
分子式：	C₄₂H₈₀ClNO₄

DOTAP chloride

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

相似产品

DOTAP chloride [orb1218933]

质量保证

化合物标识

关键属性

实验方案信息

可选规格