Elsulfavirine sodium

SKU: orb3210816

描述

Elsulfavirine sodium (R-1206 sodium) is an orally effective inhibitor of human carbonic anhydrase (CA) and an allosteric inhibitor of HIV-1 non-nucleoside reverse transcriptase (NNRT). It targets and disrupts the interaction between adenylosuccinate lyase (ADSL) and insulin-induced gene proteins INSIG1/2, blocking SREBP-1-mediated de novo lipid synthesis and inhibiting liver cancer cell proliferation. In combination with Lenvatinib, Elsulfavirine sodium exhibits synergistic antitumor effects. Inside the body, it converts to the active metabolite VM1500A, which blocks reverse transcriptase DNA polymerization activity, thereby inhibiting HIV-1 replication. The Ki values for Elsulfavirine sodium against human carbonic anhydrase subtypes I, VII, VI, VA, VB, IX, XIII, XIV range from 1960 nM to 52400 nM. This compound is utilized in research related to HIV-1 infection and liver cancer.

图片与验证

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关键属性

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CAS 号	867365-40-0
MW	652.27
分子式	C₂₄H₁₇BrCl₂FN₃NaO₅S
SMILES	[Na].N#CC1=CC(Cl)=CC(OC=2C(Br)=CC=C(C2F)CC(=O)NC3=CC=C(C=C3Cl)S(=O)(=O)NC(=O)CC)=C1
靶点	Reverse Transcriptase,Carbonic Anhydrase,HIV Protease

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

质量保证

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常用数据库链接

基因符号

Reverse Transcriptase,Carbonic Anhydrase,HIV Protease

实验方案信息

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