(-)-Epicatechin gallate

SKU: orb1226662

描述

(-)-Epicatechin gallate is a flavan-3-ol, a type of flavonoid, present in green tea.(In Vitro):(-)-Epicatechin gallate (Epicatechin gallate) exhibits >95% inhibitory activity at 70 μg/mL against cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM.(In Vivo):(-)-Epicatechin gallate (Epicatechin gallate), a component of Rhei Rhizoma, is one of the active components of Onpi-to, a herbal medicine composed of five crude drugs (Rhei Rhizome, Glycyrrhizae Radix, Ginseng Radix, Zingiberis Rhizoma and Aconiti Tuber). Following intravenous injection of (-)-Epicatechin gallate (1.0 mg/kg) in rats, the plasma concentration vs. time curve is fitted in a three compartment model. Pharmacokinetic parameters for plasma Epicatechin gallate (ECG) are measured. ECG has a t1/2α of 0.038 h, a t1/2βof 0.291 h and a t1/2γ of 4.033 h . The CLtot of ECG is 4.19 L/h kg. The Vdss is 12.39 L/kg.

图片与验证

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关键属性

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CAS 号	1257-08-5
MW	442.38
纯度	>98% (HPLC)
分子式	C₂₂H₁₈O₁₀
SMILES	O=C(O[C@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=C(C(O)=CC(O)=C3)C1)C4=CC(O)=C(O)C(O)=C4
靶点	Others
溶解性	DMSO: ≥ 30 mg/mL

生物活性

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体内

(-)-Epicatechin gallate (Epicatechin gallate), a component of Rhei Rhizoma, is one of the active components of Onpi-to, a herbal medicine composed of five crude drugs (Rhei Rhizome, Glycyrrhizae Radix, Ginseng Radix, Zingiberis Rhizoma and Aconiti Tuber). Following intravenous injection of (-)-Epicatechin gallate (1.0 mg/kg) in rats, the plasma concentration vs. time curve is fitted in a three compartment model. Pharmacokinetic parameters for plasma Epicatechin gallate (ECG) are measured. ECG has a t1/2α of 0.038 h, a t1/2βof 0.291 h and a t1/2γ of 4.033 h. The CLtot of ECG is 4.19 L/h kg. The Vdss is 12.39 L/kg.

体外

(-)-Epicatechin gallate (Epicatechin gallate) exhibits > 95% inhibitory activity at 70 μg/mL against cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM.

储存与操作

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储存	Storage temperature: -20°C. Stability: ≥ 2 years
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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ECG

相似产品

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(-)-Epicatechin gallate [orb1305097]
纯度：
99.93% (May vary between batches)
CAS 号：
1257-08-5
MW:
442.37
分子式：
C₂₂H₁₈O₁₀
可选规格： 20 mg, 1 ml x 10 mM (in DMSO)
(-)-Epicatechin-3-(3''-O-methyl) gallate [orb1940875]
纯度：
>98% (HPLC)
CAS 号：
83104-86-3
MW:
——
分子式：
——
可选规格： 5 mg, 100 mg, 200 mg, 500 mg, 1 g

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常用数据库链接

基因符号

Others

实验方案信息

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纯度：	99.93% (May vary between batches)
CAS 号：	1257-08-5
MW:	442.37
分子式：	C₂₂H₁₈O₁₀