Fenofibric acid

SKU: orb1308727

描述

Fenofibric acid is the active metabolite of the antihyperlipidemic drug fenofibrate. It is widely used in research to study lipid metabolism, acting as a PPARα agonist in both in vitro and in vivo models of dyslipidemia and atherosclerosis.

研究领域

Immunology & Inflammation, Metabolism Research, Molecular Biology, Neuroscience, Protein Biochemistry

图片与验证

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关键属性

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CAS 号	42017-89-0
MW	318.75
纯度	99.94% (May vary between batches)
分子式	C₁₇H₁₅ClO₄
SMILES	C(=O)(C1=CC=C(OC(C(O)=O)(C)C)C=C1)C2=CC=C(Cl)C=C2
靶点	PPAR,MMP,COX
溶解性	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.27 mM);DMSO:60 mg/mL (188.24 mM)

生物活性

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靶点 IC50	PPARα:22.4 µM(EC50)\|PPARδ:1.06 µM(EC50)\|COX-2:48 nM\|PPARγ:1.47 µM(EC50)
体内	Fenofibric acid attenuates aberrant increases of circulating EPC(Endothelial Progenitor Cells) in OIR mice. Inhibitory effect of Fenofibric acid on EPC mobilization in the OIR model is PPARα-dependent.Fenofibric acid Inhibits hypoxia-induced retinal EPC increase in a PPARα-dependent manner. Fenofibric acid decreases CXCR4-positive EPC in the circulation, downregulates the serum SDF-1 level and suppresses HIF-1a and SDF-1 overexpression in the retina.
体外	Fibric acids, active forms of fibrate drugs and activators of peroxisome proliferator-activated receptor-alpha (PPARα), are also known for an HDL-raising effect. Fibric acids enhance fatty acid catabolism and accordingly reduce plasma lipid level, predominantly triglyceride (TG). Fenofibric acid increases the expression of ABCA1 and apoA-I–mediated HDL production. The effect on ABCA1 expression was through the enhancement of the transcription of the ABCA1 gene being dependent on LXR.
细胞研究	PPAR activators fenofibric acid is dissolved in DMSO and added to the culture medium containing 0.2% BSA. RAW264 cells are washed with PBS and cultured an additional 48 hours in the presence of fenofibric acid in DMEM/F-12(1:1) medium containing 2% TCM and 0.2% BSA. During the last 24 hours of the drug treatment, 300 mol/L of dibutyryl cAMP and apoA-I (10 μg/mL) are added to the medium. THP-1 cells are also treated with the compound and apoA-I in 0.2% BSA-RPMI 1640 medium and 0.1% BSA-MEM. Cholesterol and choline-phospholipid released into the medium by apoA-I are determined enzymatically. Adherent cells are dissolved in 0.1 N NaOH for protein determination by bicinchoninic acid protein assay system. (Only for Reference)

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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Cyclooxygenase, COX-2, COX, MMP, inhibit, Inhibitor, NSC281318, NSC-281318, NSC 281318, Fenofibric acid, FNF acid, Trilipix, PPARα, PPAR, Peroxisome proliferator-activated receptors

相似产品

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Choline Fenofibrate [orb1303534]
纯度：
99.95% (May vary between batches)
CAS 号：
856676-23-8
MW:
421.91
分子式：
C₂₂H₂₈ClNO₅
可选规格： 10 mg, 25 mg, 100 mg, 5 mg, 50 mg, 200 mg
HR68 [orb1979954]
CAS 号：
2454582-64-8
MW:
394.85
分子式：
C₂₂H₁₉ClN₂O₃
可选规格： 1 mg, 5 mg, 10 mg, 50 mg
Fenofibric acid [orb1225082]
纯度：
>98% (HPLC)
CAS 号：
42017-89-0
MW:
318.75
分子式：
C₁₇H₁₅ClO₄
可选规格： 1 g

质量保证

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our 条款与条件和选购指南.

化合物标识

PubChem CID

64929 ↗

关键属性

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暂无计算属性。

实验方案信息

查看更多实验方案

纯度：	99.95% (May vary between batches)
CAS 号：	856676-23-8
MW:	421.91
分子式：	C₂₂H₂₈ClNO₅

CAS 号：	2454582-64-8
MW:	394.85
分子式：	C₂₂H₁₉ClN₂O₃

纯度：	>98% (HPLC)
CAS 号：	42017-89-0
MW:	318.75
分子式：	C₁₇H₁₅ClO₄

Fenofibric acid

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

相似产品

Choline Fenofibrate [orb1303534]

HR68 [orb1979954]

Fenofibric acid [orb1225082]

质量保证

化合物标识

关键属性

实验方案信息

可选规格