Golidocitinib

SKU: orb1309956

描述

Golidocitinib (AZD4205) is a potent and selective JAK1 inhibitor with an IC50 of 73 nM, demonstrating minimal activity against JAK2 and JAK3. It is a valuable research tool for investigating JAK/STAT signaling in immunological and inflammatory diseases, with utility in both in vitro and in vivo experimental models.

研究领域

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

图片与验证

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关键属性

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CAS 号	2091134-68-6
MW	489.57
纯度	>99.99% (May vary between batches)
分子式	C₂₅H₃₁N₉O₂
SMILES	COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12
靶点	JAK
溶解性	DMSO:250 mg/mL (510.65 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.21 mM)

生物活性

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靶点 IC50	JAK1:73 nM
体内	AZD4205, administered orally at doses of 12.5 mg/kg, 25 mg/kg, or 50 mg/kg twice daily (BID), exhibits dose-dependent antitumor effects when used alone. Additionally, it boosts the antitumor efficacy of osimertinib when compared to the administration of osimertinib alone in mice implanted with NCI-H1975 cells.
体外	AZD4205 significantly inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50: 161 nM).

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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AZD 4205, AZD4205, AZD-4205, Golidocitinib, Inhibitor, inhibit, Janus kinase, JAK, JAK1

质量保证

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化合物标识

PubChem CID

126715380 ↗

关键属性

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暂无计算属性。

实验方案信息

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Golidocitinib

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

质量保证

化合物标识

关键属性

实验方案信息

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