GPR75 Rabbit Polyclonal Antibody

SKU: orb574512

描述

GPR75 Rabbit Polyclonal Antibody is an unconjugated, affinity purified antibody for the detection of GPR75. It is suitable for WB application. The immunogen is a synthetic peptide directed towards the middle region of human GPR75. This antibody reacts with Human samples and is predicted to react with Bovine, Equine, Mouse, Porcine, Rabbit, Rat, Zebrafish. It is supplied as a liquid in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

研究领域

Signal Transduction

图片与验证

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Item 1 of 4

已测应用	WB
反应性	Human
预测反应性	Bovine, Equine, Mouse, Porcine, Rabbit, Rat, Zebrafish
应用说明	Application Info: Pregnenolone (3?-hydroxypregn-5-en-20-one) is the first steroid to be derived from cholesterol in the pathway of steroidogenesis, and it is the common precursor for all of the adrenal and gonadal steroids. Its production occurs in the mitochondrion by cleavage of the C-20 side chain of cholesterol by the P-450SCC enzyme. Once produced, pregnenolone may be utilized by two pathways of steroidogenesis. Pregnenolone may either be converted to 17-OH pregnenolone via the enzymatic action of 17?-hydroxylase or to progesterone via the enzymatic action of 3?-hydroxysteroid dehydrogenase. Elevated pregnenolone levels occur in forms of congenital adrenal hyperplasia (CAH), due to 3?-hydroxysteroid dehydrogenase deficiency or 17?-hydroxylase deficiencies. Higher levels have also been reported in women with idiopathic hirsutism. Studies on pregnenolone levels in regard to sex and age differences indicate that maximum levels occur at approximately 17 and 16 years of age for women and men, while minimum levels occur at approximately 37 and 38 years of age for women and men, respectively. In general, women were found to have slightly higher values when compared to men. Many areas of pregnenolone physiology remain to be investigated. Current research indicates that the determination of pregnenolone in serum may be useful for studying its metabolite, pregnenolone sulfate, which has been reported to have various effects in the mammalian brain and central nervous system.

关键属性

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宿主	Rabbit
克隆性	Polyclonal
免疫原	The immunogen is a synthetic peptide directed towards the middle region of human GPR75
靶点	GPR75
蛋白序列	Synthetic peptide located within the following region: GQSSSTPINTRIEPYYSIYNSSPSQEESSPCNLQPVNSFGFANSYIAMHY
分子量	59 kDa
纯度	>95%
纯化	Affinity Purified
偶联	Unconjugated

储存与操作

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储存	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
缓冲液/防腐剂	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
浓度	0.5 mg/ml
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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ACDC, ADPN, APM1, APM-1, GBP28, ACRP30, ADIPQTL1

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可选规格： 50 μl, 100 μl
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Bovine, Equine, Mouse, Porcine, Rabbit, Rat
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Polyclonal
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ELISA, IF, WB
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Human, Mouse
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Polyclonal
偶联：
Unconjugated
可选规格： 100 μg, 50 μg

质量保证

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our 条款与条件和选购指南.

常用数据库链接

基因符号

GPR75

UniProt

B2RC02

RefSeq（蛋白）：NP_006785

UniProt 详情

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暂无 UniProt 数据

NCBI 参考序列

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实验方案信息

免疫印迹（WB）

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应用：	ELISA, IF, WB
反应性：	Human, Mouse
克隆性：	Polyclonal
偶联：	Unconjugated

应用：	IF, WB
反应性：	Human, Mouse, Rat
种属/宿主：	Rabbit
克隆性：	Polyclonal
偶联：	Unconjugated

应用：	WB
预测反应性：	Bovine, Equine, Mouse, Porcine, Rabbit, Rat
反应性：	Human
种属/宿主：	Rabbit
克隆性：	Polyclonal
偶联：	Unconjugated