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Human Alpha-Synuclein (A53T) Pre-formed Fibrils Protein

SKU: orb3158027

描述

Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.

研究领域

Neuroscience

图片与验证

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应用说明
This protein carries no "tag". The protein has a calculated MW of 14.5 kDa.

关键属性

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表达系统E. coli
靶点Alpha-Synuclein
反应性Human
标签Native
表达区域Met 1 - Ala 140
内毒素1.0 EU per μg
偶联Unconjugated
MW14.5 kDa
纯度90%

储存与操作

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储存The product should be stored at -70°C or room temperature for short storage. Do not store fibrils on ice or at 4°C. The unsonicated fibril is validated to be stable after storage at -70°C for 1 year under sterile conditions. The sonicated fibril should be stored at -70°C for not more than 8 weeks
形态/外观Liquid
缓冲液/防腐剂PBS, pH 7.4
有效期6 months from date of receipt.
干冰运输请注意:本产品需要干冰运输,将收取干冰附加费。
免责声明For research use only

相似产品

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  • Alpha Synuclein A53T Mutant Pre-formed Fibrils [orb1822360]

    In vitro,  In vivo,  SDS-PAGE,  WB

    >95%

    ~14.46 kDa

    Recombinant

    100 μg
质量保证

质量保证

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UniProt 详情

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暂无 UniProt 数据

NCBI 参考序列

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相关登录号
基因转录本和蛋白产物的整理参考序列
RefSeqP37840, A53

实验方案信息

蛋白处理与保存指南
保存指南
查看指南

可选规格

请在下方选择规格

100 μg
¥ 14,040.00
500 μg
¥ 38,090.00
1 mg
¥ 57,850.00
发货Back order.
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