Interleukin-13 (IL-13) is a pleiotropic cytokine produced predominantly by T helper 2 (Th2) cells, mast cells, basophils, and group 2 innate lymphoid cells (ILC2s). IL-13 binds to the IL-13Rα1 subunit with low-to-moderate affinity to form an initial binary complex. This binary complex subsequently recruits the shared IL-4Rα chain to form a high-affinity heterodimeric Type II receptor complex (IL-4Rα/IL-13Rα1). The functional dimer triggers downstream intracellular signaling, primarily through the JAK/STAT6 pathway. IL-13 plays a central role in type 2 immune responses, driving IgE synthesis, goblet cell metaplasia, mucus overproduction, smooth muscle contraction, and tissue fibrosis. It is a critical driver of allergic diseases such as asthma, atopic dermatitis, chronic rhinosinusitis with nasal polyps, and eosinophilic esophagitis.
图片与验证
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应用说明
This protein . The protein has a calculated MW of 42.2 kDa (IL13RA1) & 19.0 kDa (IL13). The protein migrates as 29-39 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).
-20°C to -70°C for 12 months in lyophilized state. -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower
形态/外观
Powder
缓冲液/防腐剂
PBS, pH 7.4
有效期
6 months from date of receipt.
免责声明
For research use only
质量保证
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