IM-156 (acetate)

SKU: orb1693752

描述

IM-156 acetate is an orally bioavailable small molecule that activates AMPKα and NADH dehydrogenase while inhibiting mitochondrial oxidative phosphorylation. It has demonstrated efficacy in reducing chlorhexadiene-induced peritoneal fibrosis and suppressing tumor growth in preclinical rodent models.

图片与验证

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关键属性

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CAS 号	2043654-54-0
MW	375.35
纯度	90.00% (May vary between batches)
分子式	C₁₅H₂₀F₃N₅O₃
SMILES	O=C(O)C.FC(F)(F)OC1=CC=C(C=C1)NC(=N)NC(=N)N2CCCC2
靶点	Others
溶解性	DMF:1 mg/mL (2.66 mM);DMSO:1 mg/mL (2.66 mM);Ethanol:1 mg/mL (2.66 mM)

生物活性

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靶点 IC50	NADH dehydrogenase:2.2 µM\|OCR:3.3 µM
体内	It reduces the oxygen consumption rate (OCR; IC50 = 3.3 µM) and decreases mitochondrial ATP production in Eµ-Myc mouse lymphoma cells.1 IM-156 (10, 30, and 50 µM) increases AMPKα activity in primary rat peritoneal mesothelial cells and protects against chlorhexidine-induced peritoneal fibrosis in rats when administered at a dose of 1 mg/kg.2 It reduces tumor growth in an AT-84 murine oral cancer model and decreases age-related decline in novel object recognition, spatial working, and contextual memory in mice.
体外	IM-156 is an inhibitor of mitochondrial complex I, also known as an activator of NADH dehydrogenase (IC50 = 2.2 µM) and AMP-activated protein kinase α (AMPKα).

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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AMPK, HL 271 Acetate, HL271 Acetate, HL271 acetate, HL-271 Acetate, IM 156 Acetate, IM156 Acetate, IM-156 Acetate, OXPHOS, NADH dehydrogenase

质量保证

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化合物标识

PubChem CID

162322721 ↗

关键属性

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暂无计算属性。

实验方案信息

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IM-156 (acetate)

描述

图片与验证

关键属性

生物活性

储存与操作

别名

质量保证

化合物标识

关键属性

实验方案信息

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