Ironomycin

SKU: orb3174198

描述

Ironomycin is a derivative of Salinomycin. It exhibits selective inhibitory activity against mantle cell lymphoma (MCL) cells. Ironomycin halts the cell cycle and induces apoptosis and ferroptosis. It also causes DNA double-strand breaks and activates the unfolded protein response (UPR), specifically accumulating the IRE1α signaling pathway. Combined use of Ironomycin and Ibrutinib shows a synergistic effect. Ironomycin is useful for MCL research.

研究领域

Cell Biology, Molecular Biology, Protein Biochemistry

图片与验证

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关键属性

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CAS 号	1884647-72-6
MW	788.08
分子式	C₄₅H₇₃NO₁₀
SMILES	N(CC#C)[C@H]1[C@]2(O[C@@]3(O[C@]([C@H](C([C@H]([C@H]([C@H](C)[C@@]4(O[C@@]([C@H](C(O)=O)CC)(CC[C@@H]4C)[H])[H])O)C)=O)CC)([C@@H](C)C[C@H]3C)[H])C=C1)O[C@@](C)(CC2)[C@@]5(O[C@@H](C)[C@](CC)(O)CC5)[H]
靶点	DNA/RNA Synthesis,CDK,IRE1,Apoptosis,Caspase,Ferroptosis

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

质量保证

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常用数据库链接

基因符号

DNA/RNA Synthesis,CDK,IRE1,Apoptosis,Caspase,Ferroptosis

实验方案信息

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