JNK-IN-14

JNK-IN-14 is a potent and selective JNK inhibitor with single-digit nanomolar IC50 values against JNK1, JNK2, and JNK3 isoforms. It demonstrates robust cellular activity by inducing apoptosis, causing G2/M phase arrest, and modulating autophagy-related proteins like beclin-1 in leukemia cell models, showing superior potency to SP600125. This inhibitor is a valuable chemical probe for researching JNK signaling in oncology, neurology, and cellular stress responses both in vitro and in vivo.