LCB-2122

SKU: orb3174691

描述

LCB-2122 is an adenosine-like nucleoside analog featuring a C2'-stereoisomeric all-carbon quaternary carbon center. It inhibits doxorubicin-induced myocardial apoptosis with an IC50 value of 0.5 μM and also suppresses imatinib-induced apoptosis. LCB-2122 activates the AMPK signaling pathway, inducing the phosphorylation of AMPK and its downstream substrate acetyl-CoA carboxylase (ACC). Additionally, LCB-2122 alleviates mitochondrial damage caused by doxorubicin and is used in heart failure research.

研究领域

Cell Biology, Epigenetics & Chromatin, Metabolism Research, Molecular Biology, Signal Transduction

图片与验证

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关键属性

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CAS 号	2210298-14-7
MW	465.83
分子式	C₁₆H₂₅ClN₅O₇P
SMILES	C(O)[C@@]1(C)[C@@H](O[C@H](COP(OCC)(OCC)=O)[C@H]1O)N2C=3C(N=C2)=C(N)N=C(Cl)N3
靶点	Nucleoside Antimetabolite/Analog,Acetyl-CoA Carboxylase,AMPK,Apoptosis

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

质量保证

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常用数据库链接

基因符号

Nucleoside Antimetabolite/Analog,Acetyl-CoA Carboxylase,AMPK,Apoptosis

实验方案信息

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