LIFR/GPBAR1 modulator 1

SKU: orb3173440

描述

LIFR/GPBAR1 modulator 1 is an orally active, potent GPBAR1 agonist (EC50= 0.2 μM) and LIFR inhibitor (IC50= 7.9 μM). It enhances the expression of leukemia inhibitory factor (LIF)-mediated LIFR and GPBAR1 mRNA, while significantly reducing the expression of fibrosis markers (COL1A1, ASMA, and TGFβ), decreasing TIMP1 levels, and increasing MMP9 expression. LIFR/GPBAR1 modulator 1 is applicable for research into human fibrotic diseases.

研究领域

Pharmacology & Drug Discovery, Protein Biochemistry, Stem Cell & Developmental Biology

图片与验证

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关键属性

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靶点	MMP,TGF-beta/Smad,GPCR19

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

质量保证

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常用数据库链接

基因符号

MMP,TGF-beta/Smad,GPCR19

实验方案信息

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