Lipoprotein Lipase, Bovine

Lipoprotein Lipase, Bovine (EC 3.1.1.34), is a member of the lipase gene family and functions as a water-soluble enzyme that hydrolyzes triglycerides in lipoproteins, such as chylomicrons and very-low-density lipoproteins (VLDL), into two free fatty acid molecules and one monoacylglycerol molecule. It also facilitates the uptake of chylomicron remnants, cholesterol-rich lipoproteins, and free fatty acids by cells. The enzyme requires ApoC-II as a cofactor and is attached to the luminal surface of capillary endothelial cells via glycosylphosphatidylinositol (GPI) high-density lipoprotein-binding protein 1 (GPIHBP1) and heparan sulfate proteoglycans.