LY 303511 hydrochloride

SKU: orb1302872

描述

LY 303511 hydrochloride is a selective and potent small molecule inhibitor of the mTOR kinase. It is a valuable research tool for studying mTOR signaling pathways in both cellular and animal models of cancer, metabolic disorders, and aging-related research.

研究领域

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

图片与验证

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关键属性

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CAS 号	2070014-90-1
MW	342.82
纯度	98.47% (May vary between batches)
分子式	C₁₉H₁₉ClN₂O₂
SMILES	Cl.O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCNCC1
靶点	Potassium Channel,TNF,mTOR
溶解性	DMSO:50 mg/mL (145.85 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.83 mM)

生物活性

−

靶点 IC50

mTOR:

体外

LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. LY303511 amplifies TRAIL-induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization. LY303511 acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms.

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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LY 303511, LY 303511 Hydrochloride, LY 303511 hydrochloride, LY303511, LY-303511, LY303511 hydrochloride, LY303511 Hydrochloride, LY-303511 Hydrochloride, KcsA, inhibit, mTOR, Inhibitor, TNFR, TNF Receptor, Potassium Channel, PotassiumChannel, Tumor Necrosis Factor Receptor

质量保证

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our 条款与条件和选购指南.

化合物标识

PubChem CID

78357796 ↗

关键属性

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暂无计算属性。

实验方案信息

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LY 303511 hydrochloride

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

质量保证

化合物标识

关键属性

实验方案信息

可选规格