Mal((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-β-Glu-PAB-Exatecan

SKU: orb3028286

描述

Mal((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-β-Glu-PAB-Exatecan (LP1) is a drug-linker conjugate used for ADCs (antibody-drug conjugates). It comprises a potent DNA topoisomerase I inhibitor, Exatecan, and the linker Mal((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-β-Glu-PAB, for the synthesis of the ADC AZD0516.

研究领域

Molecular Biology, Pharmacology & Drug Discovery

图片与验证

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关键属性

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CAS 号	3059991-66-8
MW	1852.91
分子式	C₈₇H₁₁₈FN₉O₃₄
SMILES	N(C(OCC1=CC(CNC(CCNC([C@@H](NC(CCN2C(=O)C=CC2=O)=O)CCCC(N[C@@H]3[C@@]4([C@](OC3)([C@@H](NC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)CO4)[H])[H])=O)=O)=O)=C(O[C@@H]5O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]5O)C=C1)=O)[C@@H]6C7=C8C(C=9N(C8)C(=O)C%10=C(C9)[C@](CC)(O)C(=O)OC%10)=NC=%11C7=C(CC6)C(C)=C(F)C%11
靶点	Topoisomerase,Drug-Linker Conjugates for ADC

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

相似产品

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β-Glu-PAB(CH2NH2)-Exatecan [orb3027496]
CAS 号：
3025108-11-3
MW:
790.74
分子式：
C₃₉H₃₉FN₄O₁₃
可选规格： 50 mg, 10 mg

质量保证

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常用数据库链接

基因符号

Topoisomerase,Drug-Linker Conjugates for ADC

实验方案信息

查看更多实验方案

CAS 号：	3025108-11-3
MW:	790.74
分子式：	C₃₉H₃₉FN₄O₁₃