Metformin

SKU: orb1298860

描述

Metformin (1,1-Dimethylbiguanide) is a blood-brain barrier permeable AMPK activator used in type 2 diabetes research. It improves glycemic control by enhancing insulin sensitivity and reducing intestinal glucose absorption. This compound is widely applied in metabolic disease studies, including in vitro mechanistic investigations and in vivo animal models.

研究领域

Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery, Signal Transduction

图片与验证

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关键属性

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CAS 号	657-24-9
MW	129.1636
纯度	>99.99% (May vary between batches)
分子式	C₄H₁₁N₅
SMILES	CN(C)C(=N)NC(N)=N
靶点	Mitophagy,mTOR,AMPK,Apoptosis,Autophagy
溶解性	H2O:100 mg/mL (774.23 mM);DMSO:49 mg/mL (379.37 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (15.48 mM)

生物活性

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靶点 IC50	TNF-α:3.35 μM\|PANC1 cells viability:20.95 ± 0.98 mM\|B-CPAP cells viability:5.329 mM\|SARS-CoV-2 (Caco2 cells):1.43 mM\|SARS-CoV-2 (Calu3 cells):0.4 mM
体内	METHODS: To model Metformin-induced diarrhea, Metformin (125-500 mg/kg) was administered orally to healthy and diabetic obese db/db C57BL/6J mice twice daily for thirteen days. RESULTS: Metformin at 1000 mg/kg/day significantly increased fecal water content. Although no diarrhea symptoms were observed in healthy C57BL/6J mice, the same dose of Metformin induced severe diarrhea in diabetic obese db/db mice. METHODS: To investigate the protective effect of Metformin in radiation injury, Metformin (200 mg/kg once daily for three days) was administered orally to BALB/c mice, which were then exposed to 6-8 Gy of gamma radiation. RESULTS: When administered prior to exposure to radiation, Metformin prolonged the survival of mice exposed to 8 Gy-TBI and increased the survival of mice exposed to 6 Gy-TBI. Pretreatment with Metformin attenuated radiation damage.
体外	METHODS: Ovarian cancer cells A2780 and SKOV3 were treated with Metformin (0.001-50 mM) for 24-48 h. Cell viability was assayed using the MTS RESULTS: Micromolar concentrations of Metformin did not statistically reduce the viability of the A2780 or SKOV3 cell lines. At 48 h, millimolar concentrations resulted in cell death. METHODS: Human colorectal cancer cells HCT29 were treated with Metformin (0.6 mM) for 90 h. Cell motility was detected using the wound healing assay and chamber invasion assay. RESULTS: Metformin inhibited the migration and invasion of HCT29 cells, and Metformin decreased the motility of tumor cells.

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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diabetes, chain, AMPK, Autophagy, barrier, blood-brain, AMP-activated protein kinase, 1,1-Dimethylbiguanide, inhibit, liver, Mitophagy, mitochondrial, Mitochondrial Autophagy, Metformin, insulin, Inhibitor, sensitivity, respiratory, type

相似产品

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Metformin impurity 1 [orb3181523]
CAS 号：
1674-62-0
MW:
151.6
分子式：
C₃H₁₀ClN₅
可选规格： 10 mg, 50 mg
Metformin impurity 10 [orb3215776]
CAS 号：
2959-04-8
MW:
204.62
分子式：
C₄H₉ClN₈
可选规格： 10 mg, 50 mg
Metformin impurity 11 [orb3213645]
CAS 号：
1609-00-3
MW:
115.14
分子式：
C₃H₉N₅
可选规格： 10 mg, 50 mg
Metformin embonate [orb1740075]
CAS 号：
34461-22-8
MW:
646.7
分子式：
C₃₁H₃₈N₁₀O₆
可选规格： 50 mg, 100 mg, 25 mg
Metformin hydroxy analog 2 [orb2283319]
CAS 号：
98026-16-5
MW:
130.15
分子式：
C₄H₁₀N₄O
可选规格： 50 mg, 10 mg

质量保证

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化合物标识

PubChem CID

152743144 ↗

关键属性

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暂无计算属性。

实验方案信息

查看更多实验方案

CAS 号：	34461-22-8
MW:	646.7
分子式：	C₃₁H₃₈N₁₀O₆

Metformin

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

相似产品

Metformin impurity 1 [orb3181523]

Metformin impurity 10 [orb3215776]

Metformin impurity 11 [orb3213645]

Metformin embonate [orb1740075]

Metformin hydroxy analog 2 [orb2283319]

质量保证

化合物标识

关键属性

实验方案信息

可选规格