Methyl-β-cyclodextrin

SKU: orb1303195

描述

Methyl-β-cyclodextrin is a macrocyclic solubilizing agent for hydrophobic compounds. It functions as a cholesterol-depleting lipid raft disruptor, a property utilized in cell biology research to study membrane dynamics and signaling pathways in both in vitro and in vivo experimental models.

图片与验证

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关键属性

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CAS 号	128446-36-6
MW	1310 (Average)
纯度	99.45% (May vary between batches)
分子式	C₅₄H₉₄O₃₅
SMILES	COCC1OC2OC3C(COC)OC(OC4C(COC)OC(OC5C(COC)OC(OC6C(COC)OC(OC7C(COC)OC(OC8C(COC)OC(OC1C(O)C2OC)C(OC)C8O)C(OC)C7O)C(OC)C6O)C(OC)C5O)C(OC)C4O)C(OC)C3O
靶点	Others
溶解性	DMSO:55 mg/mL

生物活性

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靶点 IC50	PEL:3.33-4.23 mM.\|LPS/oxLDL-triggered monocyte-endothelial adhesion and related molecules (signalling pathway):27.66 mM\|CHO cellslesterol:14.4 μM
体内	METHODS: To test the antitumor activity in vivo, Methyl-β-cyclodextrin (500 mg/kg) was intraperitoneally injected into NRJ mice bearing PEL tumor BCBL-1 once a day for twenty-one days. RESULTS: Methyl-β-cyclodextrin significantly inhibited the growth and invasion of PEL cells without significant adverse effects. METHODS: To investigate the modulatory effects on collagen, Methyl-β-cyclodextrin (1.25-5.0 mg/mouse) was intradermally injected into the SKH1 mouse twice a week for two months. RESULTS: Methyl-β-cyclodextrin showed potent COL I up-regulatory activity resulting in increased skin thickness.
体外	METHODS: Five primary exudative lymphoma (PEL) cell lines, BCBL-1, BC-1, BC-3, TY-1, and GTO, were treated with Methyl-β-cyclodextrin (0-10 mM) for 24 h, and cell viability was measured by MTT assay. RESULTS: Methyl-β-cyclodextrin dose-dependently inhibited the growth of PEL cells with IC50 between 3.33-4.23 mM. METHODS: Chicken hepatocellular carcinoma cells, LMH, were treated with Methyl-β-cyclodextrin (10 mM) for 1 h, then cholesterol (50 µg/mL) was added at different time points before, during, and after infection with FAdV-4, and the expression levels of the target proteins were detected by Western Blot. RESULTS: When LMH cells were pretreated with increasing concentrations of Methyl-β-cyclodextrin prior to infection, penton protein levels decreased in a dose-dependent manner.
细胞研究	PEL cells are incubated in triplicate in a 96-well microculture plate in the presence of different concentrations of methyl-β-cyclodextrin (0-10 mM) in a final volume of 0.1 mL for 24 h at 37°C. Subsequently, MTT (0.5 mg/mL final concentration) is added to each well. After 3 h of additional incubation, 100 μL of a 0.04 N HCl is added to dissolve the crystals. Absorption values at 570 nm are determined.

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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beta-Cyclodextrin methyl ethers, b-Cyclodextrin methyl ethers, Methyl β cyclodextrin, Methyl-b-cyclodextrin, Methyl-beta-cyclodextrin, Methylβcyclodextrin, Methyl-β-cyclodextrin, Inhibitor, inhibit, β-Cyclodextrin methyl ethers

相似产品

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Cholesterol (Water Soluble) [orb3027307]
可选规格： 25 mg, 5 mg, 10 mg
Heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin [orb2940150]
CAS 号：
55216-11-0
MW:
1429.5424
分子式：
C₆₃H₁₁₂O₃₅
可选规格： 10 g, 1 g, 5 g
DM-β-CD [orb2942437]
CAS 号：
51166-71-3
MW:
1331.3563
分子式：
C₅₆H₉₈O₃₅
可选规格： 10 g, 50 g, 5 g
Methyl-β-cyclodextrin [orb1222777]
纯度：
>98% (HPLC)
CAS 号：
128446-36-6
MW:
1310
分子式：
C₅₄H₉₄O₃₅
可选规格： 1 g, 500 mg

质量保证

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化合物标识

PubChem CID

122143 ↗

关键属性

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暂无计算属性。

实验方案信息

查看更多实验方案

CAS 号：	55216-11-0
MW:	1429.5424
分子式：	C₆₃H₁₁₂O₃₅

CAS 号：	51166-71-3
MW:	1331.3563
分子式：	C₅₆H₉₈O₃₅

纯度：	>98% (HPLC)
CAS 号：	128446-36-6
MW:	1310
分子式：	C₅₄H₉₄O₃₅

Methyl-β-cyclodextrin

描述

图片与验证

关键属性

生物活性

储存与操作

别名

相似产品

Cholesterol (Water Soluble) [orb3027307]

Heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin [orb2940150]

DM-β-CD [orb2942437]