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特色
描述
图片与验证
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Item 1 of 12
| 已测应用 | ICC, IF, IHC-P, WB |
|---|---|
| 稀释范围 | WB: 1:200-2000, IHC-P: 1:100-500, IF/ICC: 1:100-500 |
关键属性
−| 宿主 | Rabbit |
|---|---|
| 克隆性 | Polyclonal |
| 同种型 | IgG |
| 免疫原 | KLH conjugated synthetic peptide derived from human Mlkl. Please contact us for the exact immunogen sequence. The peptide is available as orb374793. |
| 靶点 | Mlkl |
| 分子量 | 54 kDa |
| 纯度 | Polyclonal antibodies are purified by peptide affinity chromatography |
| 偶联 | Unconjugated |
储存与操作
−| 储存 | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
|---|---|
| 形态/外观 | 10 mM PBS, 0.02% sodium azide |
| 浓度 | - 100 μg (in 200 μl): 0.5 mg/ml- 200 μg (in 400 μl): 0.5 mg/ml |
| 有效期 | 12 months from date of receipt. |
| 免责声明 | For research use only |
别名
−anti-Mixed lineage kinase domain-like protein antibody, anti-Mlkl antibody
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质量保证
Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our 条款与条件和选购指南.
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Giusy Rita Caponio 1, Alessandro Annunziato 2, Mirco Vacca 2, Graziana Difonzo 2, Giuseppe Celano 2, Fabio Minervini 2, Marianna Ranieri 1, Giovanna Valenti 1, Grazia Tamma 1, Maria De Angelis Nutritional, antioxidant and biological activity characterization of orange peel flour to produce nutraceutical gluten-free muffins Food Funct, (2024)
Xing Fan 1, Fang Lin 1, Yu Chen 2, Yuling Dou 1, Ting Li 1 3, Xinxin Jin 4, Jintao Song 2, Fang Wang Luteolin-7- O-β-d-glucuronide Ameliorates Cerebral Ischemic Injury: Involvement of RIP3/MLKL Signaling Pathway Molecules, (2024)
应用
IF, WB
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Rat
Mengya Cao, Jiakai Fang, Xueqin Wang, Yi Wang, Kaiming Duan, Feng Ye, Wen Ouyang, Jianbin Tong Activation of AMP-activated protein kinase (AMPK) aggravated postoperative cognitive dysfunction and pathogenesis in aged rats Brain Research, 1684, 21 (2018)
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Xingan Wang, Michael Emmet O’Brien, Junyi Yu, Che Xu, Qiang Zhang, Songjian Lu, Lifan Liang, Xiaojing An, John F. McDyer, Rama K. Mallampalli Prolonged Cold Ischemia Induces Necroptotic Cell Death in Ischemia–Reperfusion Injury and Contributes to Primary Graft Dysfunction after Lung Transplantation American Journal of Respiratory Cell and Molecular Biology, 61, 244 (2019)
应用
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反应性
Mouse
Sublethal necroptosis signaling promotes inflammation and liver cancer Immunity, S1074-7613(23)00234-0 (2023)
Zhang, Liansheng et al. BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology iScience, 24, 102942 (2021)
Günther, Claudia et al. The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis J Clin Invest, 126, 4346-4360 (2016)
Saleh, Danish et al. Chemical Library Screens to Identify Pharmacological Modulators of Necroptosis Methods Mol. Biol., 1857, 19-33 (2018)
Marco Seehawer, Florian Heinzmann, Luana D’Artista, Jule Harbig, Pierre-François Roux, Lisa Hoenicke, Hien Dang, Sabrina Klotz, Lucas Robinson, Grégory Doré, Nir Rozenblum, Tae-Won Kang, Rishabh Chawla, Thorsten Buch, Mihael Vucur, Mareike Roth, Johannes Zuber, Tom Luedde, Bence Sipos, Thomas Longerich, Mathias Heikenwälder, Xin Wei Wang, Oliver Bischof, Lars Zender Necroptosis microenvironment directs lineage commitment in liver cancer Nature, 562, 7725 (2018)
应用
WB
反应性
Mouse
Zhou, Huiling et al. RIP1/RIP3/MLKL-mediated necroptosis contributes to vinblastine-induced myocardial damage Mol Cell Biochem, 476, 1233-1243 (2021)
Fuchslocher Chico, Johaiber et al. The enhanced susceptibility of ADAM-17 hypomorphic mice to DSS-induced colitis is not ameliorated by loss of RIPK3, revealing an unexpected function of ADAM-17 in necroptosis Oncotarget, 9, 12941-12958 (2018)
Bittel, Miriam et al. Modulation of the extrinsic cell death signaling pathway by viral Flip induces acute-death mediated liver failure Cell Death Dis, 10, 878 (2019)
Choi, Solji et al. 1-Palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol ameliorates chemoradiation-induced oral mucositis Oral Dis, 26, 111-121 (2020)
Frank, Tanja et al. Cell cycle arrest in mitosis promotes interferon-induced necroptosis Cell Death Differ, 26, 2046-2060 (2019)
Stolberg-Stolberg, Josef et al. Cartilage Trauma Induces Necroptotic Chondrocyte Death and Expulsion of Cellular Contents Int J Mol Sci, 21, 4204 (2020)
