MRX-2843

SKU: orb1308007

描述

MRX-2843 (UNC2371) is a potent, orally bioavailable small molecule inhibitor targeting MERTK and FLT3 with IC50 values of 1.3 nM and 0.64 nM, respectively. It is a valuable research tool for studying oncology, particularly in acute myeloid leukemia (AML), and has demonstrated activity in both cellular assays and in vivo tumor models.

研究领域

Cardiovascular Research, Signal Transduction

图片与验证

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关键属性

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CAS 号	1429882-07-4
MW	488.67
纯度	99.63% (May vary between batches)
分子式	C₂₉H₄₀N₆O
SMILES	CN1CCN(Cc2ccc(cc2)-c2cn([C@H]3CC[C@H](O)CC3)c3nc(NCCC4CC4)ncc23)CC1
靶点	FLT
溶解性	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.09 mM);DMSO:26.25 mg/mL (53.72 mM)

生物活性

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靶点 IC50	FLT3:0.64 nM\|MerTK:1.3 nM
体内	In murine orthotopic xenograft models, once-daily oral therapy prolonged survival 2- to 3-fold over that of vehicle-treated controls. Additionally, MRX-2843 retained activity against quizartinib-resistant FLT3-ITD-mutant proteins with clinically relevant alterations at the D835 or F691 loci and prolonged survival in xenograft models of quizartinib-resistant AML. Together, these observations validate MRX-2843 as a translational agent and support its clinical development for the treatment of AML.
体外	MRX-2843, a type 1 small-molecule tyrosine kinase inhibitor that abrogates activation of both MERTK and FLT3 and their downstream effectors. MRX-2843 treatment induces apoptosis and inhibits colony formation in AML cell lines and primary patient samples expressing MERTK and/or FLT3-ITD, with a wide therapeutic window compared with that of normal human cord blood cells.

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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MRX-2843, MRX 2843, MRX2843, inhibit, MERTK, Inhibitor, FLT3, Fms like tyrosine kinase 3, CD135, Cluster of differentiation antigen 135, UNC2371, UNC-2371, UNC 2371

相似产品

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MRX-2843 [orb1220102]
纯度：
>98% (HPLC)
CAS 号：
1429882-07-4
MW:
488.67
分子式：
C₂₉H₄₀N₆O
可选规格： 5 mg, 25 mg, 50 mg, 100 mg, 10 mg, 200 mg, 500 mg, 1 g

质量保证

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our 条款与条件和选购指南.

化合物标识

PubChem CID

89495685 ↗

关键属性

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暂无计算属性。

实验方案信息

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纯度：	>98% (HPLC)
CAS 号：	1429882-07-4
MW:	488.67
分子式：	C₂₉H₄₀N₆O

MRX-2843

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

相似产品

MRX-2843 [orb1220102]

质量保证

化合物标识

关键属性

实验方案信息

可选规格