MSC778

SKU: orb3173123

描述

MSC778 is a selective and orally active inhibitor of flap endonuclease 1 (FEN1), with an IC50 of 3 nM and a KD of 2.9 nM. It exhibits 145-fold, 516-fold, and 65-fold selectivity over EXO1, GEN1, and XPG, respectively. MSC778 selectively targets BRCA2-deficient cells and enhances the tumor-stalling activity of Niraparib in BRCA2 KO DLD-1 mouse xenografts. It is applicable in colorectal cancer research.

研究领域

Immunology & Inflammation

图片与验证

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关键属性

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CAS 号	3098173-17-9
MW	441.87
分子式	C₂₂H₂₀ClN₃O₅
SMILES	O=C1C=2N(C[C@@]3(N1CCOC3)[H])N=C(O[C@@H](C)C4=CC5=C(C=C4)C=CC(Cl)=C5)C(=O)C2O
靶点	FLAP

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

质量保证

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常用数据库链接

基因符号

FLAP

实验方案信息

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