MYCi975

SKU: orb1219642

描述

MYCi975 is an orally active inhibitor of MYC.MYCi975 inhibits P493-6, MV411,SK-N-B2 cells viability in an MYC-dependent manner(IC50s of 3.7, 3.9, 6.4 μM, respectively)[1].The initial lead, MYC inhibitor 361 (MYCi361), suppressed in vivo tumor growth in mice, increased tumor immune cell infiltration, upregulated PD-L1 on tumors, and sensitized tumors to anti-PD1 immunotherapy. However, 361 demonstrated a narrow therapeutic index. An improved analog, MYCi975 showed better tolerability.

图片与验证

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关键属性

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CAS 号	2289691-01-4
MW	561.3
纯度	>98% (HPLC)
分子式	C₂₅H₁₆Cl₂F₆N₂O₂
SMILES	Cn1nc(cc1-c1ccc(OCc2ccc(Cl)cc2)c(-c2ccc(Cl)c(c2)C(F)(F)F)c1O)C(F)(F)F
靶点	c-Myc
溶解性	DMSO:247 mg/mL (440.05mM)

储存与操作

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储存	Storage temperature: -20°C. Stability: ≥ 2 years
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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NUCC-0200975

相似产品

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MYCi975 [orb1709073]
纯度：
99.82% (May vary between batches)
CAS 号：
2289691-01-4
MW:
561.303
分子式：
C₂₅H₁₆Cl₂F₆N₂O₂
可选规格： 5 mg, 10 mg, 25 mg, 50 mg, 1 mg, 1 ml x 10 mM (in DMSO)

质量保证

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常用数据库链接

基因符号

c-Myc

实验方案信息

查看更多实验方案

纯度：	99.82% (May vary between batches)
CAS 号：	2289691-01-4
MW:	561.303
分子式：	C₂₅H₁₆Cl₂F₆N₂O₂