NADPH tetrasodium salt

SKU: orb1220605

描述

NADPH tetrasodium salt is the reduced form of the electron acceptor nicotinamide adenine dinucleotide phosphate (NADP+) and acts as an electron donor in various biological reactions.

研究领域

Metabolism Research

图片与验证

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关键属性

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CAS 号	2646-71-1
MW	833.35
纯度	>98% (HPLC)
分子式	C₂₁H₂₆N₇Na₄O₁₇P₃
SMILES	[Na+].[Na+].[Na+].[Na+].NC(=O)C1=CN(C=CC1)C1OC(COP([O-])(=O)OP([O-])(=O)OCC2OC(C(OP([O-])([O-])=O)C2O)n2cnc3c(N)ncnc23)C(O)C1O
靶点	Others
溶解性	H2O:35 mg/mL (42.00 mM)

生物活性

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体外

NADPH tetrasodium salt de novo synthesis is catalyzed by NAD kinases (NADKs), which catalyze the phosphorylation of NAD+ to form NADP+. NADPH tetrasodium salt is mainly involved in catabolic reactions, whereas NADPH tetrasodium salt is primarily involved in cellular antioxidative effects and anabolic reactions. NADPH tetrasodium salt is used by glutathione reductase (GR) to reduce oxidized glutathione (GSSG) to GSH. The regeneration rate of NADPH tetrasodium salt is often the rate-limiting step for the over-production of desired chemicals, while maintaining robust cellular growth. NADPH tetrasodium salt homeostasis is regulated by varied signaling pathways and several metabolic enzymes that undergo adaptive alteration in cancer cells. The metabolic reprogramming of NADPH tetrasodium salt renders cancer cells both highly dependent on this metabolic network for antioxidant capacity and more susceptible to oxidative stress. NADPH tetrasodium salt is an essential intracellular reductant needed to eliminate lipid hydroperoxides. Indeed, NADPH tetrasodium salt levels are a biomarker of ferroptosis sensitivity across many cancer cell lines.

储存与操作

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储存	Storage temperature: -20°C. Stability: ≥ 2 years
有效期	12 months from date of receipt.
免责声明	For research use only

相似产品

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NADPH tetrasodium salt [orb1300081]
纯度：
99.99% (May vary between batches)
CAS 号：
2646-71-1
MW:
833.35
分子式：
C₂₁H₂₆N₇Na₄O₁₇P₃
可选规格： 50 mg, 100 mg, 200 mg

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基因符号

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实验方案信息

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纯度：	99.99% (May vary between batches)
CAS 号：	2646-71-1
MW:	833.35
分子式：	C₂₁H₂₆N₇Na₄O₁₇P₃