NCC Antibody (HRP)

SKU: orb152702

描述

Rabbit polyclonal to NCC (HRP). NCC, a thiazide-sensitive NaCl co-transporter, is found on the apical membrane of the distal convoluted tubule, where it is the principal mediator of Na+ and Cl- reabsorption in this segment of the nephron. It is activated by phosphorylation, and has been implicated in renal NaCl and K+ homeostasis. Regulation of NCC expression and phosphorylation by dietary NACl restriction appears to involve SGK1(1). In experiments with angiotensin II-infused mice, increased sensitivity to Ang II may involved over-activity of NCC. Therefore, NCC is the target of thiazide diuretics used in the treatment of hypertension. Molecular experiments have also shown that NCC has been detected in the lens cortex, core and fiber cells of a rat..

研究领域

Cancer Biology, Neuroscience, Pharmacology & Drug Discovery

图片与验证

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已测应用	ICC, IEM, IF, IHC, WB
稀释范围	WB (1:1000), IHC (1:200)
反应性	Canine, Human, Mouse, Rat
应用说明	1 µg/ml was sufficient for detection of NCC3 in 10 µg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

关键属性

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宿主	Rabbit
克隆性	Polyclonal
免疫原	Produced against a synthetic peptide mapping to a segment of rat NCC (amino acids 74-95), N-terminal
靶点	NCC
分子量	160kDa
纯化	Affinity Purified
偶联	HRP

储存与操作

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储存	Conjugated antibodies should be stored according to the product label
缓冲液/防腐剂	73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide, 0.23mM Citrate
浓度	1 mg/ml
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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NCC, SLC12A3, SCYL1, CKb10, MCP-4, MGC17134, NCC-1, NCC1, SCYA13, CK-beta-10, Monocyte chemoattractant protein 4, Monocyte chemotactic protein 4, New CC chemokine 1, Small inducible cytokine A13, Small inducible cytokine subfamily A (Cys-Cys) member 13, Chemokine (C-C)

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