Orelabrutinib

SKU: orb1219759

描述

Orelabrutinib is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK). (In Vitro):With a proprietary formulation, Orelabrutinib (ICP-022) achieves high bioavailability comparing to other BTK inhibitors.(In Vivo):Upon administration, Orelabrutinib (ICP-022) binds to and inhibits the activity of BTK. This prevents both the activation of the B-cell antigen receptor (BCR) signaling pathway and BTK-mediated activation of downstream survival pathways, inhibiting the growth of malignant B-cells that overexpress BTK.

图片与验证

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关键属性

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CAS 号	1655504-04-3
MW	427.5
纯度	>98% (HPLC)
分子式	C₂₆H₂₅N₃O₃
SMILES	NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(CC1)C(=O)C=C
靶点	BTK
溶解性	DMSO:250 mg/mL (584.80 mM; Need ultrasonic)

生物活性

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体内	Upon administration, Orelabrutinib (ICP-022) binds to and inhibits the activity of BTK. This prevents both the activation of the B-cell antigen receptor (BCR) signaling pathway and BTK-mediated activation of downstream survival pathways, inhibiting the growth of malignant B-cells that overexpress BTK.
体外	With a proprietary formulation, Orelabrutinib (ICP-022) achieves high bioavailability comparing to other BTK inhibitors.

储存与操作

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储存	Storage temperature: -20°C. Stability: ≥ 2 years
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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ICP-022

相似产品

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Orelabrutinib [orb1309294]
纯度：
99.54% (May vary between batches)
CAS 号：
1655504-04-3
MW:
427.49
分子式：
C₂₆H₂₅N₃O₃
可选规格： 5 mg, 10 mg, 50 mg, 100 mg, 1 mg, 25 mg, 500 mg, 1 ml x 10 mM (in DMSO)

质量保证

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常用数据库链接

基因符号

BTK

实验方案信息

查看更多实验方案

纯度：	99.54% (May vary between batches)
CAS 号：	1655504-04-3
MW:	427.49
分子式：	C₂₆H₂₅N₃O₃