PD 198306

SKU: orb1306133

描述

PD 198306 is a selective MEK inhibitor exhibiting antihyperalgesic properties. It effectively attenuates the Streptozocin-induced elevation of active ERK1 levels, making it a useful research tool for studying MAPK/ERK signaling in diabetic neuropathy models both in vitro and in vivo.

研究领域

Signal Transduction

图片与验证

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关键属性

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CAS 号	212631-61-3
MW	476.23
纯度	99.75% (May vary between batches)
分子式	C₁₈H₁₆F₃IN₂O₂
SMILES	N(C1=C(C(NOCC2CC2)=O)C=C(F)C(F)=C1F)C3=C(C)C=C(I)C=C3
靶点	MEK
溶解性	DMSO:45 mg/mL (94.49 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.5 mM)

生物活性

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体内	In male Sprague Dawley rats bearing neuropathic pain, PD 198306 (1-30 μg/10 μL; i.t.) dose-dependently blocks static allodynia in both the chronic constriction injury and the streptozocin models.
体外	PD 198306 (10 μM) reduces Tha-Crimson replication by 30% at 18 h and 50% at 36 h. PD 198306 (10 μM) significantly inhibits Tha-GFP replication by 25%.

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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rabies, phosphatases, phosphate, screening, RNA, antihyperalgesic, drug, inhibit, Inhibitor, kinases, neuropathic, Mitogen-activated protein kinase kinase, mitogen-activated protein, PD 198306, PD198306, PD-198306, pain, ERK, inositol, interference, MAPK, MAP2K, MAPKK, MEK

质量保证

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化合物标识

PubChem CID

9956637 ↗

关键属性

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暂无计算属性。

实验方案信息

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PD 198306

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

质量保证

化合物标识

关键属性

实验方案信息

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