PD98059

SKU: orb1225975

描述

PD98059 (PD 098059) is a specific MEK inhibitor with IC50 of ~10 uM without significant inhibitory activity of MAPK; prevents activation of MAPK and subsequent phosphorylation of MAPK substrates both in vitro and in intact cells.(In Vitro):PD98059 (20 μM; 24 hours) causes G1-phase cell cycle arrest in OCI-AML-3 cells.PD98059 (10 μM; 22 hours) results in concentration-dependent reductions in the dually phosphorylated forms of ERK1 and ERK2. PD98059 both prevents ERK activation and blocks formation of TDP-43 and HuR-positive SGs.(In Vivo):PD98059 (10 mg/kg; i.p.; 1 and 6 hours after Zymosan) significantly reduces the level of p-ERK1/2 in zymosan-injected mice.

图片与验证

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关键属性

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CAS 号	167869-21-8
MW	267.2793
纯度	>98% (HPLC)
分子式	C₁₆H₁₃NO₃
SMILES	O=C1C=C(C2=CC=CC(OC)=C2N)OC3=C1C=CC=C3
靶点	MEK
溶解性	DMSO: 16 mg/mL; H2O: < 0.01 mg/mL

生物活性

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体内	Animal model: Male CD mice. Dosage: 10 mg/kg. Administration: Intraperitoneal injection; 1 and 6 hours after Zymosan. Result: Significantly reduced the level of p-ERK1/2.
体外	Cell Cycle Analysis Cell line: OCI-AML-3 cells. Concentration: 20 μM. Incubation time: 24 hours. Result: Caused G1-phase cell cycle arrest. Western blot analysis. Cell line: MCF10A-Neo, MCF10ANeoT cells. Concentration: 10 μM. Incubation time: 22 hours. Result: Phosphorylated ERK forms were almost completely eliminated in both cell lines.

储存与操作

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储存	Storage temperature: -20°C. Stability: ≥ 2 years
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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PD 098059 | PD-98059

相似产品

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PD-98059 [orb1305254]
纯度：
>98%
CAS 号：
167869-21-8
MW:
267.29
分子式：
C₁₆H₁₃NO₃
可选规格： 5 mg, 25 mg

质量保证

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常用数据库链接

基因符号

MEK

实验方案信息

查看更多实验方案

纯度：	>98%
CAS 号：	167869-21-8
MW:	267.29
分子式：	C₁₆H₁₃NO₃