PERK,Akt,EGFR Antibody

SKU: orb3131544

描述

GC1118 (GC-1118A) is a fully human anti-EGFR monoclonal antibody with a KD value of 0.16 nM against EGFR. It potently inhibits signal transduction triggered by both high-affinity and low-affinity EGFR ligands. GC1118 exhibits strong antiproliferative activity in both KRAS wild-type and KRAS mutant cells. It can penetrate the blood-brain barrier (BBB) and blood-tumor barrier (BTB) to reach tumor sites and demonstrates excellent antitumor effects in various mouse xenograft models. GC1118 is applicable for cancer studies, including colorectal cancer.

研究领域

Cardiovascular Research, Cell Biology, Signal Transduction

图片与验证

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关键属性

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抗体类型	Inhibitor Antibody
克隆性	Monoclonal
靶点	PERK,Akt,EGFR
偶联	Unconjugated

储存与操作

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储存	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
有效期	12 months from date of receipt.
免责声明	For research use only

质量保证

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our 条款与条件和选购指南.

常用数据库链接

基因符号

PERK,Akt,EGFR

实验方案信息

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