PF-06873600

SKU: orb1298913

描述

PF-06873600 is an orally bioavailable, selective CDK2/4/6 inhibitor with low nanomolar Ki values. It exhibits antineoplastic activity and has been investigated in preclinical studies for cancer research, demonstrating effects in both cellular and animal models of various malignancies.

研究领域

Cell Biology

图片与验证

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关键属性

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CAS 号	2185857-97-8
MW	471.52
纯度	99.58% (May vary between batches)
分子式	C₂₀H₂₇F₂N₅O₄S
SMILES	C[C@@]1(O)CCC[C@H]1n1c2nc(NC3CCN(CC3)S(C)(=O)=O)ncc2cc(C(F)F)c1=O
靶点	CDK
溶解性	DMSO:150 mg/mL (318.12 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7 mM)

生物活性

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靶点 IC50	CDK6:0.16 nM (Ki)\|CDK4:0.13 nM (Ki)\|CDK2:0.09 nM (Ki)
体外	PF-06873600 selectively targets, binds to and inhibits the activity of CDKs. Inhibition of these kinases leads to cell cycle arrest, induction of apoptosis and inhibition of tumor cell proliferation. CDKs, ATP-dependent serine/threonine kinases that are important regulators of cell cycle progression and cellular proliferation, are frequently overexpressed in tumor cells.

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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CDK2, PF 06873600, PF06873600, PF-06873600, PF3600

相似产品

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(S)-PF-06873600 [orb1708609]
纯度：
99.12% (May vary between batches)
CAS 号：
2185859-59-8
MW:
471.52
分子式：
C₂₀H₂₇F₂N₅O₄S
可选规格： 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO)
(S)-PF-06873600 [orb2901716]
纯度：
>98% (HPLC)
CAS 号：
2185859-59-8
MW:
471.52
分子式：
C₂₀H₂₇F₂N₅O₄S
可选规格： 10 mg, 25 mg, 50 mg, 100 mg, 2 mg, 5 mg, 500 mg, 1 g

质量保证

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our 条款与条件和选购指南.

化合物标识

PubChem CID

134247638 ↗

关键属性

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暂无计算属性。

实验方案信息

查看更多实验方案

纯度：	99.12% (May vary between batches)
CAS 号：	2185859-59-8
MW:	471.52
分子式：	C₂₀H₂₇F₂N₅O₄S

纯度：	>98% (HPLC)
CAS 号：	2185859-59-8
MW:	471.52
分子式：	C₂₀H₂₇F₂N₅O₄S

PF-06873600

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

相似产品

(S)-PF-06873600 [orb1708609]

(S)-PF-06873600 [orb2901716]

质量保证

化合物标识

关键属性

实验方案信息

可选规格