Plogosertib

SKU: orb1738081

描述

Plogosertib (CYC140) is a potent, selective, and orally bioavailable ATP-competitive inhibitor of PLK1 (IC50=3 nM). It demonstrates robust antiproliferative effects in vitro and has shown promising antitumor activity in vivo, supporting its research use in both solid and hematological cancer models.

研究领域

Cell Biology

图片与验证

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关键属性

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CAS 号	1137212-79-3
MW	616.797
纯度	>99.99% (May vary between batches)
分子式	C₃₄H₄₈N₈O₃
SMILES	O=C1C2(CN(C=3C(N1C)=CN=C(NC4=C(OC)C=C(C(N[C@@H]5CC[C@H](CC5)N6CCN(C)CC6)=O)C=C4)N3)C7CCCC7)CC2
靶点	PLK

生物活性

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靶点 IC50	PLK1:3 nM\|PLK2:149 nM\|PLK3:393 nM
体内	In the HL60 promyelocytic leukemia xenograft model, Plogosertib (40, 54, 67 mg/kg, qd 5/2/5; oral administration) inhibited tumor growth (>87%) without significant loss in body weight.
体外	In KYSE-410 cells, Plogosertib (0, 0.07, 0.15, 0.3, 0.6, 1.25 μM; 72 hours) inhibits cell proliferation in a concentration-dependent manner.

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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CYC 140, CYC140, CYC-140, AC 220, AC 010220, AC-220, AC010220, AC-010220, AC010220.2HCl, PLK1, Plogosertib, Quizartinib, Quizartinib dihydrochloride, Quizartinib HCl

质量保证

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our 条款与条件和选购指南.

化合物标识

PubChem CID

42640739 ↗

关键属性

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暂无计算属性。

实验方案信息

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Plogosertib

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

质量保证

化合物标识

关键属性

实验方案信息

可选规格