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描述
研究领域
图片与验证
−| 已测应用 | IHC-P |
|---|---|
| 稀释范围 | IHC-P: 1:100-1:500 |
| 反应性 | Human, Mouse, Rat |
关键属性
−| 宿主 | Rabbit |
|---|---|
| 克隆性 | Polyclonal |
| 同种型 | IgG |
| 免疫原 | KLH conjugated synthetic peptide derived from human RANK. Please contact us for the exact immunogen sequence. The peptide is available as orb393922. |
| 靶点 | RANK |
| 分子量 | 130kDa |
| 纯度 | Purified by Protein A affinity chromatography. |
| 偶联 | Unconjugated |
储存与操作
−| 储存 | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
|---|---|
| 形态/外观 | 10 mM PBS, 0.02% sodium azide |
| 浓度 | - 100 μg (in 200 μl): 0.5 mg/ml- 200 μg (in 400 μl): 0.5 mg/ml |
| 有效期 | 12 months from date of receipt. |
| 免责声明 | For research use only |
别名
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质量保证
Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our 条款与条件和选购指南.
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Sahin Sultana, Biswadev Bishayi Neutralization of TNFR-1 and TNFR-2 modulates S. aureus induced septic arthritis by regulating the levels of pro inflammatory and anti inflammatory cytokines during the progression of the disease Immunology Letters, 196, 33 (2018)
应用
反应性
Ayantika Kundu 1, Pratiti Ghosh 2, Biswadev Bishayi Verapamil and tangeretin enhances the M1 macrophages to M2 type in lipopolysaccharide-treated mice and inhibits the P-glycoprotein expression by downregulating STAT1/STAT3 and upregulating SOCS3 Int Immunopharmacol, (2024)
应用
反应性
Sahin Sultana, Rajen Dey, Biswadev Bishayi Dual neutralization of TNFR-2 and MMP-2 regulates the severity of S. aureus induced septic arthritis correlating alteration in the level of interferon gamma and interleukin-10 in terms of TNFR2 blocking Immunologic Research, 66, 97 (2018)
应用
反应性
Gopinath Mukherjee 1, Sharmistha Samanta 1, Biswadev Bishayi TLR-4Ab and IFNγAb with exogenous IL-10 treated LPS induced mice shown differential inflammatory response upon RANKL-M-CSF stimulation in Resident Bone Marrow Cells Microb Pathog, (2025)
应用
反应性
Sahin Sultana, Biswadev Bishayi Potential anti-arthritic and anti-inflammatory effects of TNF-α processing inhibitor-1 (TAPI-1): A new approach to the treatment of S. aureus arthritis Immunobiology, 225, 151887 (2019)
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反应性
Sahin Sultana, Rajen Dey, Biswadev Bishayi Role of plasminogen activator inhibitor – 1 (PAI-1) in regulating the pathogenesis of S. aureus arthritis via plasminogen pathway Immunology Letters, 209, 53 (2019)
应用
反应性
Ghosh, Rituparna et al. Simultaneous neutralization of TGF-? and IL-6 attenuates Staphylococcus aureus-induced arthritic inflammation through differential modulation of splenic and synovial macrophages Scand J Immunol, e13252 (2023)
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Murray, Jonathan B. et al. Activation of (pro)renin by (pro)renin receptor in extracellular vesicles from osteoclasts Sci Rep, 11, 9214 (2021)
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