Recombinant CD8 Antibody (alpha chain) / Rabbit Monoclonal

SKU: orb2640339

描述

CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.

研究领域

Immunology & Inflammation

图片与验证

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已测应用	IHC-P
稀释范围	The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
反应性	Human
应用说明	The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the recombinant CD8 antibody to be titered up or down for optimal performance.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

关键属性

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抗体类型	Primary Antibody
宿主	Rabbit
克隆性	Recombinant
同种型	Rabbit IgG, kappa
克隆号	C8/1779R
免疫原	Recombinant full-length human CD8a protein was used as immunogen for this recombinant CD8 antibody.
纯化	Protein A affinity chromatography
偶联	Unconjugated

储存与操作

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储存	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
缓冲液/防腐剂	Prediluted in 1X PBS, 0.1 mg/ml rAlbumin, 0.05% sodium azide; For IHC use only
有效期	12 months from date of receipt.
免责声明	For research use only

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Recombinant CD8 Antibody (alpha chain) / Rabbit Monoclonal [orb386200]
应用：
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种属/宿主：
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克隆性：
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可选规格： 100 μg, 20 μg
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Recombinant CD8 Antibody (alpha chain) / Rabbit Monoclonal [orb2640340]
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种属/宿主：
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IHC-P
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Recombinant
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IHC-P
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Recombinant CD8 Antibody (alpha chain) / Rabbit Monoclonal [orb2640875]
应用：
IHC-P
反应性：
Human
种属/宿主：
Rabbit
克隆性：
Recombinant
偶联：
Unconjugated
可选规格： 100 μg

质量保证

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our 条款与条件和选购指南.

常用数据库链接

UniProt

P01732

UniProt 详情

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暂无 UniProt 数据

实验方案信息

IHC-P

石蜡切片免疫组化

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