Resveratrol

SKU: orb1308192

特色

描述

Resveratrol (SRT 501) is a polyphenolic plant antitoxin studied for its antioxidant and chemopreventive properties. It modulates targets like COX and SIRT, and research in vitro and in vivo shows it can induce autophagy and apoptosis, supporting its investigation in cancer and aging-related studies.

研究领域

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Stem Cell & Developmental Biology

图片与验证

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关键属性

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CAS 号	501-36-0
MW	228.3
纯度	>98%
分子式	C₁₄H₁₂O₃
SMILES	OC1=CC=C(C=C1)\C=C\C1=CC(O)=CC(O)=C1
靶点	Protein deacetylase
溶解性	Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).

生物活性

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靶点 IC50	DNA polymerase δ:5 μM (cell free)\|COX-2:1.3 μM (cell free)\|Adenylyl cyclase:0.8 nM\|IKKβ:1 μM\|COX-1:1.1 μM (cell free)\|DNA polymerase α:3.3 μM (cell free)\|DNA polymerase δ:5 μM (cell free)\|DNA polymerase α:3.3 μM (cell free)
体内	METHODS: To assay anti-tumor activity in vivo, Resveratrol (50-100 mg/kg, 5% ethanol and 25% polyethyleneglycol 400 in distilled water) was intraperitoneally injected into BALB/c (nu/nu) mice harboring the human ovarian teratoma PA-1 once daily for four weeks. RESULTS: Resveratrol inhibited the growth of PA-1 cell xenografts and eEF1A2 expression. METHODS: To study the effects on depressed mice, Resveratrol (10-30 mg/kg) was administered intraperitoneally once daily for 21 days to C57BL/6 mice, a model of depression. RESULTS: Resveratrol significantly increased the levels of the prefrontal cortex neurotransmitters DA and 5-HT, and increased the expression of NPY in the brain, which antagonized depression.
体外	METHODS: Mouse mammary carcinoma cells 4T1 were treated with Resveratrol (50-250 μM) for 72 h. Cell viability was measured by CCK-8. RESULTS: Resveratrol dose-dependently inhibited the viability of 4T1 cells with an IC50 of 93 μM. METHODS: Human breast cancer cells MCF-7 were treated with Resveratrol (1-100 μM) for 24 h, and the intracellular ATP content was detected by luciferin-luciferase assay. RESULTS: Resveratrol decreased the cellular ATP content. It was reduced by about 16% at 1 μM Resveratrol and 50% at 100 μM Resveratrol.
细胞研究	HAECs were treated with RSV in the presence of isobutylmethylxanthine (IBMX). The reaction was stopped by adding ice-cold 6% trichloroacetic acid and the supernatant fractions of the cellular lysates were extracted, dried and acetylated. Cyclic GMP levels were determined by an enzyme immunoassay kit and results standardized by protein levels .
动物研究	Eight-week male apoE-/- mice (C57BL/6 background) were used in the study. Mice were housed in photobiologic light-exposure chambers with a 12:12-h light:dark cycle, and eat food ad libitum. Mice were randomly divided into two groups: one group receiving a high cholesterol diet (HCD, 21% fat, 19.5% casein, and 1.5% cholesterol), the other receiving HCD supplemented with RSV (200 mg/100 g diet). All mice were fed for 8 weeks. To identify the potential role of PKA, some mice were treated with PKA specific inhibitor (KT5720, 1.2 mg/kg) via intraperitoneal injection once a day at the last 4 weeks. The animal experiments were conducted according to the institutional guidelines of Guangdong Provincial People's Hospital .

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3,benzenediol

相似产品

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Item 1 of 1
General Resveratrol (RVT) ELISA Kit [orb782094]
反应性：
All
动态范围：
312.5-20000 ng/mL
灵敏度：
91.1 ng/mL
可选规格： 48 T, 96 T
Item 1 of 1
Grape Skin Standards Kit [orb322055]
可选规格： 1 kit
Azo-Resveratrol [orb1146559]
纯度：
>98%
CAS 号：
1393556-48-3
MW:
482.484087467194
分子式：
C₂₈H₂₂N₂O₆
可选规格： 100 mg, 250 mg, 1 g
Resveratrol 12-C-beta-glucopyranoside [orb3159332]
纯度：
>=98%
CAS 号：
163527-00-2
MW:
390.4
分子式：
C₂₀H₂₂O₈
可选规格： 10 mg
VINST1 Antibody [orb833658]
应用：
ELISA, WB
种属/宿主：
Rabbit
克隆性：
Polyclonal
偶联：
Unconjugated
可选规格： 2 mg

质量保证

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our 条款与条件和选购指南.

化合物标识

PubChem CID

445154 ↗

关键属性

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暂无计算属性。

实验方案信息

查看更多实验方案

反应性：	All
动态范围：	312.5-20000 ng/mL
灵敏度：	91.1 ng/mL

纯度：	>98%
CAS 号：	1393556-48-3
MW:	482.484087467194
分子式：	C₂₈H₂₂N₂O₆

纯度：	>=98%
CAS 号：	163527-00-2
MW:	390.4
分子式：	C₂₀H₂₂O₈

应用：	ELISA, WB
种属/宿主：	Rabbit
克隆性：	Polyclonal
偶联：	Unconjugated

Resveratrol

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

相似产品

General Resveratrol (RVT) ELISA Kit [orb782094]

Grape Skin Standards Kit [orb322055]

Azo-Resveratrol [orb1146559]

Resveratrol 12-C-beta-glucopyranoside [orb3159332]

VINST1 Antibody [orb833658]

质量保证

化合物标识

关键属性

实验方案信息

可选规格