Rosuvastatin

SKU: orb1225424

描述

A potent, competitive inhibitor of HMG-CoA reductase (HMGCR) with IC50 of 11 nM; potently inhibits cholesterol biosynthesis (IC50=1.12 nM) in rat isolated hepatocytes, 100 times more potent than pravastatin; also exerts important anti-inflammatory effects via inhibition of endothelial cell adhesion molecule expression.Dyslipidemia Approved(In Vivo):Rosuvastatin Calcium (10 mg/kg, intraperitoneal) prolonges QTc in conscious and unrestraines guinea pigs from 201±1 to 210±2 ms.Rosuvastatin (20 mg/kg/day, for 2 weeks) significantly reduces very low-density lipoproteins Calcium (VLDL) in diabetes mellitus rats induced by Streptozocin.

研究领域

Pharmacology & Drug Discovery

图片与验证

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关键属性

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CAS 号	287714-41-4
MW	481.5376
纯度	>98% (HPLC)
分子式	C₂₂H₂₈FN₃O₆S
SMILES	CC(C)C1=NC(=NC(=C1/C=C/[C@H](C[C@H](CC(=O)O)O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C
靶点	HMGCR
溶解性	10 mM in DMSO

生物活性

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体内	Rosuvastatin (10 mg/kg, intraperitoneal) prolonges QTc in conscious and unrestraines guinea pigs from 201±1 to 210±2 ms. Rosuvastatin (20 mg/kg/day, for 2 weeks) significantly reduces very low-density lipoproteins (VLDL) in diabetes mellitus rats induced by Streptozocin.

储存与操作

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储存	Storage temperature: -20°C. Stability: ≥ 2 years
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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ZD-4522

相似产品

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Item 1 of 1
Rosuvastatin . calcium salt [orb1227518]
纯度：
greater than or equal to 98% (HPLC)
CAS 号：
147098-20-2
MW:
480.6 . 20.0
分子式：
C₂₂H₂₇FN₃O₆S . 1/2Ca
可选规格： 250 mg
Rosuvastatin impurity 40 calcium [orb3216952]
可选规格： 50 mg, 10 mg
Rosuvastatin impurity 33 [orb3217089]
CAS 号：
615556-96-2
MW:
535.63
分子式：
C₂₆H₃₄FN₃O₆S
可选规格： 50 mg, 10 mg
Rosuvastatin impurity 34 [orb3217159]
CAS 号：
1347797-73-2
MW:
483.55
分子式：
C₂₂H₃₀FN₃O₆S
可选规格： 50 mg, 10 mg
Rosuvastatin impurity 41 [orb3217165]
CAS 号：
1283766-30-2
MW:
523.62
分子式：
C₂₅H₃₄FN₃O₆S
可选规格： 50 mg, 10 mg

质量保证

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常用数据库链接

基因符号

HMGCR

实验方案信息

查看更多实验方案

纯度：	greater than or equal to 98% (HPLC)
CAS 号：	147098-20-2
MW:	480.6 . 20.0
分子式：	C₂₂H₂₇FN₃O₆S . 1/2Ca

CAS 号：	615556-96-2
MW:	535.63
分子式：	C₂₆H₃₄FN₃O₆S

CAS 号：	1347797-73-2
MW:	483.55
分子式：	C₂₂H₃₀FN₃O₆S

CAS 号：	1283766-30-2
MW:	523.62
分子式：	C₂₅H₃₄FN₃O₆S

Rosuvastatin

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

相似产品

Rosuvastatin . calcium salt [orb1227518]

Rosuvastatin impurity 40 calcium [orb3216952]

Rosuvastatin impurity 33 [orb3217089]

Rosuvastatin impurity 34 [orb3217159]

Rosuvastatin impurity 41 [orb3217165]

质量保证

常用数据库链接

实验方案信息

可选规格