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(S)-Sunvozertinib

SKU: orb1298200

描述

(S)-Sunvozertinib (DZD9008) is an irreversible, selective inhibitor targeting EGFR and HER2 tyrosine kinases. It is a research tool for investigating oncogenic mutations in preclinical models, demonstrating activity in both cellular assays and in vivo studies against EGFR-mutant cancers, including those with exon 20 insertions.

研究领域

Cardiovascular Research, Signal Transduction

图片与验证

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关键属性

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CAS 号2370013-49-1
MW584.08
纯度99.69% (May vary between batches)
分子式C29H35ClFN7O3
SMILESCOc1cc(N2CC[C@@H](C2)N(C)C)c(NC(=O)C=C)cc1Nc1nccc(Nc2cc(Cl)c(F)cc2C(C)(C)O)n1
靶点BTK,EGFR,HER
溶解性10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.42 mM);DMSO:55 mg/mL (94.17 mM)

生物活性

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靶点 IC50
EGFR (exon 20 NPH):51.2 nM (IC50)|EGFR (L858R/T790M):1 nM (IC50)|HER2 exon20 YVMA insertion:21.2 nM (IC50)|EGFR (exon 20 ASV insertion):51.9 nM (IC50)

储存与操作

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储存-20°C
有效期12 months from date of receipt.
免责声明For research use only

别名

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Btk, Bruton tyrosine kinase, (S) Sunvozertinib, (S)-DZD9008, (S)Sunvozertinib, (S)-Sunvozertinib, DZD 9008, DZD9008, DZD-9008, breast cancer, Epidermal growth factor receptor, ErbB-1, EGFR, HER2, HER1, Her2, Inhibitor, mutant forms of ErbB, inhibit, lung, N-[5-[[4-[5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide, Sunvozertinib
质量保证

质量保证

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our 条款与条件和选购指南.

关键属性

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暂无计算属性。

实验方案信息

可选规格

请在下方选择规格

1 mg
¥ 1,300.00
5 mg
¥ 2,210.00
1 ml x 10 mM (in DMSO)
¥ 2,730.00
10 mg
¥ 3,120.00
25 mg
¥ 4,810.00
50 mg
¥ 6,500.00
100 mg
¥ 8,970.00
发货Usually dispatched within 5-10 working days
批量询价