SM-102

SKU: orb1298110

特色

描述

SM-102 is a clinically approved ionizable cationic lipid used to formulate lipid nanoparticles (LNPs) for mRNA delivery. It is a key component in research for developing mRNA vaccines and therapeutics, with applications in both in vitro and in vivo studies.

研究领域

Metabolism Research

图片与验证

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Item 1 of 1

关键属性

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CAS 号	2089251-47-6
MW	710.165
纯度	99.97% (May vary between batches)
分子式	C₄₄H₈₇NO₅
SMILES	O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCO)CCCCCC(OCCCCCCCCCCC)=O
靶点	Liposome,Others
溶解性	DMSO: 55 mg/mL (77.45 mM), Sonication is recommended. Ethanol: 100 mg/mL (140.81 mM), Sonication is recommended.

生物活性

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靶点 IC50

IK (erg):108 μM|IK (erg) (MA-10 cells):98 μM

体外

METHODS: The effects of SM-102 on ionic currents in two endocrine cells, rat pituitary tumor (GH3) cells and mouse Leydig tumor (MA-10) cells, or microglial cells (BV2), were investigated. Hyperpolarization-activated K currents in these cells bathed in a high-K, Ca2+-free extracellular solution were examined to assess the effects of SM-102 on the amplitude and hysteresis of erg-mediated K currents (I+K(erg)). RESULTS The addition of SM-102 effectively blocked IK(erg) in a concentration-dependent manner with a half-peak concentration (IC50) of 108 μM, which was similar to the KD value required for its enhanced current inactivation time constant (i.e., 134 μM); in the presence of SM-102, exposure of cells to the transfection reagent TurboFectinTM 8.0 (0.1%, v/v) was able to effectively inhibit hyperpolarization-activated IK(erg) and increase the inactivation time course of the current; in addition, in GH3 cells dialyzed with spermine (30 μM), the amplitude of IK(erg) gradually decreased; further use of SM-102 (100 μM) or TurboFectin (0.1%) further reduced the current amplitude; in MA-10 Leydig cells, the IC50 value of SM-102-induced IK(erg) inhibition in MA-10 cells was 98 μM. In BV2 microglia, the amplitude of inwardly rectifying K currents is inhibited by SM-102.

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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SM102, SM-102, SM 102, vaccines, COVID-19, delivery, mRNA, lipid nanoparticle, inhibit, Inhibitor

相似产品

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Item 1 of 1
SM102 Analog 1 [orb1786014]
纯度：
>98%
CAS 号：
2089251-55-6
MW:
822.4
分子式：
C₅₂H₁₀₃NO₅
可选规格： 250 mg, 1 g, 100 mg
Iso-A11B5C1 [orb2279869]
纯度：
0.98
MW:
663.1
分子式：
C₄₁H₇₉N₃O₃
可选规格： 25 mg
Lipid GVS-18-B6 [orb2279901]
纯度：
0.95
MW:
594.528
分子式：
C₃₆H₇₁NO₃Si
可选规格： 50 mg, 25 mg, 100 mg
SM-102 IMPURITY 2 [orb1818904]
纯度：
>98%
CAS 号：
2824195-50-6
MW:
725.65
分子式：
44H₈₇NO₆
可选规格： 100 mg
Fluorescent-SM102 [orb2703777]
纯度：
>98%
MW:
828.15
分子式：
C₄₅H₇₉N₅O₈
可选规格： 25 mg, 50 mg

质量保证

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our 条款与条件和选购指南.

化合物标识

PubChem CID

126697616 ↗

关键属性

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暂无计算属性。

实验方案信息

查看更多实验方案

Bradley Diggines et al. Navigating Lipid Nanostructure Design Space Through Continuous Microfluidic Automation Adv Mater, (2026)

PubMed: 42504485

纯度：	>98%
CAS 号：	2089251-55-6
MW:	822.4
分子式：	C₅₂H₁₀₃NO₅

纯度：	0.98
MW:	663.1
分子式：	C₄₁H₇₉N₃O₃

纯度：	0.95
MW:	594.528
分子式：	C₃₆H₇₁NO₃Si

SM-102

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

相似产品

SM102 Analog 1 [orb1786014]

Iso-A11B5C1 [orb2279869]

Lipid GVS-18-B6 [orb2279901]

SM-102 IMPURITY 2 [orb1818904]

Fluorescent-SM102 [orb2703777]

质量保证

化合物标识

关键属性

实验方案信息

可选规格