Phenylbutyrate Na

SKU: orb1308290

特色

描述

Sodium 4-phenylbutyrate

研究领域

Cell Biology, Epigenetics & Chromatin, Stem Cell & Developmental Biology

图片与验证

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关键属性

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CAS 号	1716-12-7
MW	186.2
纯度	>98%
分子式	C₁₀H₁₁O₂ • Na
SMILES	[Na+].[O-]C(=O)CCCC1=CC=CC=C1
靶点	Protein deacetylase
溶解性	Soluble in DMSO (up to 4 mg/ml) or in Water (up to 25 mg/ml).

生物活性

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体内	In prostate cancer cells, Phenylbutyrate induces apoptosis by diminishing the expression levels of the cell apoptosis antagonist Bcl-X(L), the double-strand break repair protein DNA-dependent protein kinase, the prostate progression marker Caveolin-1, and the angiogenesis promoter Vascular Endothelial Growth Factor, thereby weakening their activity.
体外	In G93A transgenic ALS mice, Phenylbutyrate improves clinical symptoms and increases survival. It induces the expression of NF-κB p50 in G93A mice, while reducing the expression of cytochrome c and caspases. Additionally, in transgenic mouse models of Huntington's disease (HD), Phenylbutyrate elevates brain protein acetylation levels and reduces histone methylation levels.

储存与操作

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储存	RT
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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4-PB; PBNa

质量保证

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化合物标识

PubChem CID

5258 ↗

关键属性

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暂无计算属性。

实验方案信息

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Phenylbutyrate Na

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

质量保证

化合物标识

关键属性

实验方案信息

可选规格